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Biology of Mood & Anxiety Disorders

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  1. Content type: Research

    Coordination of activity between the amygdala and ventromedial prefrontal cortex (vmPFC) is important for fear-extinction learning. Aberrant recruitment of this circuitry is associated with anxiety disorders. ...

    Authors: Jayne Morriss, Anastasia Christakou and Carien M. van Reekum

    Citation: Biology of Mood & Anxiety Disorders 2015 5:4

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  2. Content type: Review

    Post-traumatic stress disorder (PTSD) is accompanied by disturbed sleep and an impaired ability to learn and remember extinction of conditioned fear. Following a traumatic event, the full spectrum of PTSD symp...

    Authors: Edward F. Pace-Schott, Anne Germain and Mohammed R. Milad

    Citation: Biology of Mood & Anxiety Disorders 2015 5:3

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  3. Content type: Research

    Previous research reported that individual differences in the stress response were moderated by an interaction between individuals’ life stress experience and the serotonin transporter-linked polymorphic regio...

    Authors: Elif A Duman and Turhan Canli

    Citation: Biology of Mood & Anxiety Disorders 2015 5:2

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  4. Content type: Perspective

    There is growing interest in the use of neuroimaging for the direct treatment of mental illness. Here, we present a new framework for such treatment, neurocognitive therapeutics. What distinguishes neurocognit...

    Authors: David M Schnyer, Christopher G Beevers, Megan T deBettencourt, Stephanie M Sherman, Jonathan D Cohen, Kenneth A Norman and Nicholas B Turk-Browne

    Citation: Biology of Mood & Anxiety Disorders 2015 5:1

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  5. Content type: Research

    Obsessive-compulsive disorder (OCD) is a common and debilitating neuropsychiatric illness thought to involve abnormal connectivity of widespread brain networks, including frontal-striatal-thalamic circuits. At...

    Authors: Isabelle M Rosso, Elizabeth A Olson, Jennifer C Britton, S Evelyn Stewart, George Papadimitriou, William DS Killgore, Nikos Makris, Sabine Wilhelm, Michael A Jenike and Scott L Rauch

    Citation: Biology of Mood & Anxiety Disorders 2014 4:13

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  6. Content type: Research

    Childhood onset of anxiety disorders is associated with greater functional impairment and burden across the lifespan. Recent work suggests that generalized anxiety disorder (GAD) is characterized by dysfunctio...

    Authors: Lisa L Hamm, Rachel H Jacobs, Meghan W Johnson, Daniel A Fitzgerald, Kate D Fitzgerald, Scott A Langenecker, Christopher S Monk and K Luan Phan

    Citation: Biology of Mood & Anxiety Disorders 2014 4:15

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  7. Content type: Research

    Aberrant amygdala-prefrontal interactions at rest and during emotion processing are implicated in the pathophysiology of generalized social anxiety disorder (gSAD), a common disorder characterized by fears of ...

    Authors: Heide Klumpp, Michael K Keutmann, Daniel A Fitzgerald, Stewart A Shankman and K Luan Phan

    Citation: Biology of Mood & Anxiety Disorders 2014 4:14

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  8. Content type: Research

    The experience of early life stress is a consistently identified risk factor for the development of mood and anxiety disorders. Preclinical research employing animal models of early life stress has made inroad...

    Authors: Adam X Gorka, Jamie L Hanson, Spenser R Radtke and Ahmad R Hariri

    Citation: Biology of Mood & Anxiety Disorders 2014 4:12

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  9. Content type: Research

    It has long been suggested that feedback signals from facial muscles influence emotional experience. The recent surge in use of botulinum toxin (BTX) to induce temporary muscle paralysis offers a unique opport...

    Authors: M Justin Kim, Maital Neta, F Caroline Davis, Erika J Ruberry, Diana Dinescu, Todd F Heatherton, Mitchell A Stotland and Paul J Whalen

    Citation: Biology of Mood & Anxiety Disorders 2014 4:11

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  10. Content type: Brief Report

    Prior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. However, no study to date has investigated the neural correlates of unpredictable ...

    Authors: Stephanie M Gorka, Brady D Nelson, K Luan Phan and Stewart A Shankman

    Citation: Biology of Mood & Anxiety Disorders 2014 4:9

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  11. Content type: Research

    Scientists are beginning to document abnormalities in white matter connectivity in major depressive disorder (MDD). Recent developments in diffusion-weighted image analyses, including tractography clustering m...

    Authors: Matthew D Sacchet, Gautam Prasad, Lara C Foland-Ross, Shantanu H Joshi, J Paul Hamilton, Paul M Thompson and Ian H Gotlib

    Citation: Biology of Mood & Anxiety Disorders 2014 4:8

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  12. Content type: Research

    Previous functional imaging studies using symptom provocation in patients with social anxiety disorder (SAD) reported inconsistent findings, which might be at least partially related to different time-dependen...

    Authors: Stephanie Boehme, Alexander Mohr, Michael PI Becker, Wolfgang HR Miltner and Thomas Straube

    Citation: Biology of Mood & Anxiety Disorders 2014 4:6

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  13. Content type: Research

    Animal studies have suggested that the hippocampus may play an important role in anxiety as part of the Behavioural Inhibition System (BIS), which mediates reactivity to threat and punishment and can predict a...

    Authors: Liat Levita, Catherine Bois, Andrew Healey, Emily Smyllie, Evelina Papakonstantinou, Tom Hartley and Colin Lever

    Citation: Biology of Mood & Anxiety Disorders 2014 4:4

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  14. Content type: Research

    Premenstrual dysphoric disorder (PMDD), characterized by luteal phase-induced negative affect and loss of impulse control, often results in compromised social interactions. Although amygdala activation is gene...

    Authors: Malin Gingnell, Victoria Ahlstedt, Elin Bannbers, Johan Wikström, Inger Sundström-Poromaa and Mats Fredrikson

    Citation: Biology of Mood & Anxiety Disorders 2014 4:3

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  15. Content type: Research

    Recent studies examining the interaction between the 5-HTTLPR locus in the serotonin transporter gene and life stress in predicting depression have yielded equivocal results, leading some researchers to questi...

    Authors: Christopher C Conway, George M Slavich and Constance Hammen

    Citation: Biology of Mood & Anxiety Disorders 2014 4:2

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  16. Content type: Research

    Corticotropin-releasing factor type 2 receptors (CRFR2) are suggested to facilitate successful recovery from stress to maintain mental health. They are abundant in the midbrain raphe nuclei, where they regulat...

    Authors: Orna Issler, Roderick N Carter, Evan D Paul, Paul AT Kelly, Henry J Olverman, Adi Neufeld-Cohen, Yael Kuperman, Christopher A Lowry, Jonathan R Seckl, Alon Chen and Pauline M Jamieson

    Citation: Biology of Mood & Anxiety Disorders 2014 4:1

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  17. Content type: Research

    Early adverse experiences, especially those involving disruption of the mother-infant relationship, are detrimental for proper socioemotional development in primates. Humans with histories of childhood maltrea...

    Authors: Brittany R Howell, Kai M McCormack, Alison P Grand, Nikki T Sawyer, Xiaodong Zhang, Dario Maestripieri, Xiaoping Hu and Mar M Sanchez

    Citation: Biology of Mood & Anxiety Disorders 2013 3:21

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  18. Content type: Research

    Changes in glucocorticoid receptors (GRs) have been implicated in the pathogenesis of stress related psychiatric disorders such as depression and post-traumatic stress disorder (PTSD). Abnormal adaptation of t...

    Authors: Sophie A George, Stephanie A Stout, Melissa Tan, Dayan Knox and Israel Liberzon

    Citation: Biology of Mood & Anxiety Disorders 2013 3:22

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  19. Content type: Research

    Social anxiety disorder (SAD) is thought to involve deficits in emotion regulation, and more specifically, deficits in cognitive reappraisal. However, evidence for such deficits is mixed.

    Authors: Michal Ziv, Philippe R Goldin, Hooria Jazaieri, Kevin S Hahn and James J Gross

    Citation: Biology of Mood & Anxiety Disorders 2013 3:20

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  20. Content type: Review

    Several mental illnesses, including anxiety, can manifest during development, with onsets in late childhood. Understanding the neurobiological underpinnings of risk for anxiety is of crucial importance for ear...

    Authors: Tanja Jovanovic, Karin Maria Nylocks and Kaitlyn L Gamwell

    Citation: Biology of Mood & Anxiety Disorders 2013 3:17

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