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  1. Perspective

    Neurocognitive therapeutics: from concept to application in the treatment of negative attention bias

    There is growing interest in the use of neuroimaging for the direct treatment of mental illness. Here, we present a new framework for such treatment, neurocognitive therapeutics. What distinguishes neurocognit...

    David M Schnyer, Christopher G Beevers, Megan T deBettencourt, Stephanie M Sherman, Jonathan D Cohen, Kenneth A Norman and Nicholas B Turk-Browne

    Biology of Mood & Anxiety Disorders 2015 5:1

    Published on: 18 April 2015

  2. Research

    Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder

    Obsessive-compulsive disorder (OCD) is a common and debilitating neuropsychiatric illness thought to involve abnormal connectivity of widespread brain networks, including frontal-striatal-thalamic circuits. At...

    Isabelle M Rosso, Elizabeth A Olson, Jennifer C Britton, S Evelyn Stewart, George Papadimitriou, William DS Killgore, Nikos Makris, Sabine Wilhelm, Michael A Jenike and Scott L Rauch

    Biology of Mood & Anxiety Disorders 2014 4:13

    Published on: 18 December 2014

  3. Research

    Aberrant amygdala functional connectivity at rest in pediatric anxiety disorders

    Childhood onset of anxiety disorders is associated with greater functional impairment and burden across the lifespan. Recent work suggests that generalized anxiety disorder (GAD) is characterized by dysfunctio...

    Lisa L Hamm, Rachel H Jacobs, Meghan W Johnson, Daniel A Fitzgerald, Kate D Fitzgerald, Scott A Langenecker, Christopher S Monk and K Luan Phan

    Biology of Mood & Anxiety Disorders 2014 4:15

    Published on: 9 December 2014

  4. Research

    Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder

    Aberrant amygdala-prefrontal interactions at rest and during emotion processing are implicated in the pathophysiology of generalized social anxiety disorder (gSAD), a common disorder characterized by fears of ...

    Heide Klumpp, Michael K Keutmann, Daniel A Fitzgerald, Stewart A Shankman and K Luan Phan

    Biology of Mood & Anxiety Disorders 2014 4:14

    Published on: 9 December 2014

  5. Research

    Reduced hippocampal and medial prefrontal gray matter mediate the association between reported childhood maltreatment and trait anxiety in adulthood and predict sensitivity to future life stress

    The experience of early life stress is a consistently identified risk factor for the development of mood and anxiety disorders. Preclinical research employing animal models of early life stress has made inroad...

    Adam X Gorka, Jamie L Hanson, Spenser R Radtke and Ahmad R Hariri

    Biology of Mood & Anxiety Disorders 2014 4:12

    Published on: 13 November 2014

  6. Research

    Botulinum toxin-induced facial muscle paralysis affects amygdala responses to the perception of emotional expressions: preliminary findings from an A-B-A design

    It has long been suggested that feedback signals from facial muscles influence emotional experience. The recent surge in use of botulinum toxin (BTX) to induce temporary muscle paralysis offers a unique opport...

    M Justin Kim, Maital Neta, F Caroline Davis, Erika J Ruberry, Diana Dinescu, Todd F Heatherton, Mitchell A Stotland and Paul J Whalen

    Biology of Mood & Anxiety Disorders 2014 4:11

    Published on: 31 October 2014

  7. Brief Report

    Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression

    Prior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. However, no study to date has investigated the neural correlates of unpredictable ...

    Stephanie M Gorka, Brady D Nelson, K Luan Phan and Stewart A Shankman

    Biology of Mood & Anxiety Disorders 2014 4:9

    Published on: 7 October 2014

  8. Research

    Structural abnormality of the corticospinal tract in major depressive disorder

    Scientists are beginning to document abnormalities in white matter connectivity in major depressive disorder (MDD). Recent developments in diffusion-weighted image analyses, including tractography clustering m...

    Matthew D Sacchet, Gautam Prasad, Lara C Foland-Ross, Shantanu H Joshi, J Paul Hamilton, Paul M Thompson and Ian H Gotlib

    Biology of Mood & Anxiety Disorders 2014 4:8

    Published on: 10 September 2014

  9. Research

    Area-dependent time courses of brain activation during video-induced symptom provocation in social anxiety disorder

    Previous functional imaging studies using symptom provocation in patients with social anxiety disorder (SAD) reported inconsistent findings, which might be at least partially related to different time-dependen...

    Stephanie Boehme, Alexander Mohr, Michael PI Becker, Wolfgang HR Miltner and Thomas Straube

    Biology of Mood & Anxiety Disorders 2014 4:6

    Published on: 28 April 2014

  10. Research

    The Behavioural Inhibition System, anxiety and hippocampal volume in a non-clinical population

    Animal studies have suggested that the hippocampus may play an important role in anxiety as part of the Behavioural Inhibition System (BIS), which mediates reactivity to threat and punishment and can predict a...

    Liat Levita, Catherine Bois, Andrew Healey, Emily Smyllie, Evelina Papakonstantinou, Tom Hartley and Colin Lever

    Biology of Mood & Anxiety Disorders 2014 4:4

    Published on: 7 March 2014

  11. Research

    Social stimulation and corticolimbic reactivity in premenstrual dysphoric disorder: a preliminary study

    Premenstrual dysphoric disorder (PMDD), characterized by luteal phase-induced negative affect and loss of impulse control, often results in compromised social interactions. Although amygdala activation is gene...

    Malin Gingnell, Victoria Ahlstedt, Elin Bannbers, Johan Wikström, Inger Sundström-Poromaa and Mats Fredrikson

    Biology of Mood & Anxiety Disorders 2014 4:3

    Published on: 26 February 2014

  12. Research

    Daily stress reactivity and serotonin transporter gene (5-HTTLPR) variation: internalizing responses to everyday stress as a possible transdiagnostic phenotype

    Recent studies examining the interaction between the 5-HTTLPR locus in the serotonin transporter gene and life stress in predicting depression have yielded equivocal results, leading some researchers to questi...

    Christopher C Conway, George M Slavich and Constance Hammen

    Biology of Mood & Anxiety Disorders 2014 4:2

    Published on: 24 January 2014

  13. Research

    Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas

    Corticotropin-releasing factor type 2 receptors (CRFR2) are suggested to facilitate successful recovery from stress to maintain mental health. They are abundant in the midbrain raphe nuclei, where they regulat...

    Orna Issler, Roderick N Carter, Evan D Paul, Paul AT Kelly, Henry J Olverman, Adi Neufeld-Cohen, Yael Kuperman, Christopher A Lowry, Jonathan R Seckl, Alon Chen and Pauline M Jamieson

    Biology of Mood & Anxiety Disorders 2014 4:1

    Published on: 21 January 2014

  14. Research

    Brain white matter microstructure alterations in adolescent rhesus monkeys exposed to early life stress: associations with high cortisol during infancy

    Early adverse experiences, especially those involving disruption of the mother-infant relationship, are detrimental for proper socioemotional development in primates. Humans with histories of childhood maltrea...

    Brittany R Howell, Kai M McCormack, Alison P Grand, Nikki T Sawyer, Xiaodong Zhang, Dario Maestripieri, Xiaoping Hu and Mar M Sanchez

    Biology of Mood & Anxiety Disorders 2013 3:21

    Published on: 2 December 2013

  15. Research

    Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder

    Changes in glucocorticoid receptors (GRs) have been implicated in the pathogenesis of stress related psychiatric disorders such as depression and post-traumatic stress disorder (PTSD). Abnormal adaptation of t...

    Sophie A George, Stephanie A Stout, Melissa Tan, Dayan Knox and Israel Liberzon

    Biology of Mood & Anxiety Disorders 2013 3:22

    Published on: 2 December 2013

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