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  1. Content type: Research

    Coordination of activity between the amygdala and ventromedial prefrontal cortex (vmPFC) is important for fear-extinction learning. Aberrant recruitment of this circuitry is associated with anxiety disorders. ...

    Authors: Jayne Morriss, Anastasia Christakou and Carien M. van Reekum

    Citation: Biology of Mood & Anxiety Disorders 2015 5:4

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  2. Content type: Review

    Post-traumatic stress disorder (PTSD) is accompanied by disturbed sleep and an impaired ability to learn and remember extinction of conditioned fear. Following a traumatic event, the full spectrum of PTSD symp...

    Authors: Edward F. Pace-Schott, Anne Germain and Mohammed R. Milad

    Citation: Biology of Mood & Anxiety Disorders 2015 5:3

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  3. Content type: Research

    Previous research reported that individual differences in the stress response were moderated by an interaction between individuals’ life stress experience and the serotonin transporter-linked polymorphic regio...

    Authors: Elif A Duman and Turhan Canli

    Citation: Biology of Mood & Anxiety Disorders 2015 5:2

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  4. Content type: Perspective

    There is growing interest in the use of neuroimaging for the direct treatment of mental illness. Here, we present a new framework for such treatment, neurocognitive therapeutics. What distinguishes neurocognit...

    Authors: David M Schnyer, Christopher G Beevers, Megan T deBettencourt, Stephanie M Sherman, Jonathan D Cohen, Kenneth A Norman and Nicholas B Turk-Browne

    Citation: Biology of Mood & Anxiety Disorders 2015 5:1

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  5. Content type: Research

    Obsessive-compulsive disorder (OCD) is a common and debilitating neuropsychiatric illness thought to involve abnormal connectivity of widespread brain networks, including frontal-striatal-thalamic circuits. At...

    Authors: Isabelle M Rosso, Elizabeth A Olson, Jennifer C Britton, S Evelyn Stewart, George Papadimitriou, William DS Killgore, Nikos Makris, Sabine Wilhelm, Michael A Jenike and Scott L Rauch

    Citation: Biology of Mood & Anxiety Disorders 2014 4:13

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  6. Content type: Research

    Childhood onset of anxiety disorders is associated with greater functional impairment and burden across the lifespan. Recent work suggests that generalized anxiety disorder (GAD) is characterized by dysfunctio...

    Authors: Lisa L Hamm, Rachel H Jacobs, Meghan W Johnson, Daniel A Fitzgerald, Kate D Fitzgerald, Scott A Langenecker, Christopher S Monk and K Luan Phan

    Citation: Biology of Mood & Anxiety Disorders 2014 4:15

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  7. Content type: Research

    Aberrant amygdala-prefrontal interactions at rest and during emotion processing are implicated in the pathophysiology of generalized social anxiety disorder (gSAD), a common disorder characterized by fears of ...

    Authors: Heide Klumpp, Michael K Keutmann, Daniel A Fitzgerald, Stewart A Shankman and K Luan Phan

    Citation: Biology of Mood & Anxiety Disorders 2014 4:14

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  8. Content type: Research

    The experience of early life stress is a consistently identified risk factor for the development of mood and anxiety disorders. Preclinical research employing animal models of early life stress has made inroad...

    Authors: Adam X Gorka, Jamie L Hanson, Spenser R Radtke and Ahmad R Hariri

    Citation: Biology of Mood & Anxiety Disorders 2014 4:12

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  9. Content type: Research

    It has long been suggested that feedback signals from facial muscles influence emotional experience. The recent surge in use of botulinum toxin (BTX) to induce temporary muscle paralysis offers a unique opport...

    Authors: M Justin Kim, Maital Neta, F Caroline Davis, Erika J Ruberry, Diana Dinescu, Todd F Heatherton, Mitchell A Stotland and Paul J Whalen

    Citation: Biology of Mood & Anxiety Disorders 2014 4:11

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  10. Content type: Brief Report

    Prior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. However, no study to date has investigated the neural correlates of unpredictable ...

    Authors: Stephanie M Gorka, Brady D Nelson, K Luan Phan and Stewart A Shankman

    Citation: Biology of Mood & Anxiety Disorders 2014 4:9

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  11. Content type: Research

    Scientists are beginning to document abnormalities in white matter connectivity in major depressive disorder (MDD). Recent developments in diffusion-weighted image analyses, including tractography clustering m...

    Authors: Matthew D Sacchet, Gautam Prasad, Lara C Foland-Ross, Shantanu H Joshi, J Paul Hamilton, Paul M Thompson and Ian H Gotlib

    Citation: Biology of Mood & Anxiety Disorders 2014 4:8

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  12. Content type: Research

    Previous functional imaging studies using symptom provocation in patients with social anxiety disorder (SAD) reported inconsistent findings, which might be at least partially related to different time-dependen...

    Authors: Stephanie Boehme, Alexander Mohr, Michael PI Becker, Wolfgang HR Miltner and Thomas Straube

    Citation: Biology of Mood & Anxiety Disorders 2014 4:6

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  13. Content type: Research

    Animal studies have suggested that the hippocampus may play an important role in anxiety as part of the Behavioural Inhibition System (BIS), which mediates reactivity to threat and punishment and can predict a...

    Authors: Liat Levita, Catherine Bois, Andrew Healey, Emily Smyllie, Evelina Papakonstantinou, Tom Hartley and Colin Lever

    Citation: Biology of Mood & Anxiety Disorders 2014 4:4

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  14. Content type: Research

    Premenstrual dysphoric disorder (PMDD), characterized by luteal phase-induced negative affect and loss of impulse control, often results in compromised social interactions. Although amygdala activation is gene...

    Authors: Malin Gingnell, Victoria Ahlstedt, Elin Bannbers, Johan Wikström, Inger Sundström-Poromaa and Mats Fredrikson

    Citation: Biology of Mood & Anxiety Disorders 2014 4:3

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  15. Content type: Research

    Recent studies examining the interaction between the 5-HTTLPR locus in the serotonin transporter gene and life stress in predicting depression have yielded equivocal results, leading some researchers to questi...

    Authors: Christopher C Conway, George M Slavich and Constance Hammen

    Citation: Biology of Mood & Anxiety Disorders 2014 4:2

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  16. Content type: Research

    Corticotropin-releasing factor type 2 receptors (CRFR2) are suggested to facilitate successful recovery from stress to maintain mental health. They are abundant in the midbrain raphe nuclei, where they regulat...

    Authors: Orna Issler, Roderick N Carter, Evan D Paul, Paul AT Kelly, Henry J Olverman, Adi Neufeld-Cohen, Yael Kuperman, Christopher A Lowry, Jonathan R Seckl, Alon Chen and Pauline M Jamieson

    Citation: Biology of Mood & Anxiety Disorders 2014 4:1

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  17. Content type: Research

    Early adverse experiences, especially those involving disruption of the mother-infant relationship, are detrimental for proper socioemotional development in primates. Humans with histories of childhood maltrea...

    Authors: Brittany R Howell, Kai M McCormack, Alison P Grand, Nikki T Sawyer, Xiaodong Zhang, Dario Maestripieri, Xiaoping Hu and Mar M Sanchez

    Citation: Biology of Mood & Anxiety Disorders 2013 3:21

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  18. Content type: Research

    Changes in glucocorticoid receptors (GRs) have been implicated in the pathogenesis of stress related psychiatric disorders such as depression and post-traumatic stress disorder (PTSD). Abnormal adaptation of t...

    Authors: Sophie A George, Stephanie A Stout, Melissa Tan, Dayan Knox and Israel Liberzon

    Citation: Biology of Mood & Anxiety Disorders 2013 3:22

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  19. Content type: Research

    Social anxiety disorder (SAD) is thought to involve deficits in emotion regulation, and more specifically, deficits in cognitive reappraisal. However, evidence for such deficits is mixed.

    Authors: Michal Ziv, Philippe R Goldin, Hooria Jazaieri, Kevin S Hahn and James J Gross

    Citation: Biology of Mood & Anxiety Disorders 2013 3:20

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  20. Content type: Review

    Several mental illnesses, including anxiety, can manifest during development, with onsets in late childhood. Understanding the neurobiological underpinnings of risk for anxiety is of crucial importance for ear...

    Authors: Tanja Jovanovic, Karin Maria Nylocks and Kaitlyn L Gamwell

    Citation: Biology of Mood & Anxiety Disorders 2013 3:17

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  21. Content type: Research

    Extinction learning is proposed to be one key mechanism of action underlying exposure-based cognitive-behavioral therapy (CBT) in specific phobia. Beyond that, cognitive reappraisal, one important strategy to ...

    Authors: Andrea Hermann, Verena Leutgeb, Wilfried Scharmüller, Dieter Vaitl, Anne Schienle and Rudolf Stark

    Citation: Biology of Mood & Anxiety Disorders 2013 3:16

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  22. Content type: Review

    Although several psychological and pharmacological treatment options are available for anxiety disorders, not all patients respond well to each option. Furthermore, given the relatively long duration of adequa...

    Authors: Lisa M Shin, F Caroline Davis, Michael B VanElzakker, Mary K Dahlgren and Stacey J Dubois

    Citation: Biology of Mood & Anxiety Disorders 2013 3:15

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  23. Content type: Review

    Social Anxiety Disorder (SAD) is a common and debilitating condition that typically manifests in adolescence. Here we describe cognitive factors engaged by brain-imaging tasks, which model the peer-based socia...

    Authors: Johanna M Jarcho, Ellen Leibenluft, Olga Lydia Walker, Nathan A Fox, Daniel S Pine and Eric E Nelson

    Citation: Biology of Mood & Anxiety Disorders 2013 3:14

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  24. Content type: Research

    Various neuropsychiatric conditions, including posttraumatic stress disorder (PTSD), are characterized by deficient fear extinction, but individuals differ greatly in risk for these. While there is growing evi...

    Authors: Kathryn MacPherson, Nigel Whittle, Marguerite Camp, Ozge Gunduz-Cinar, Nicolas Singewald and Andrew Holmes

    Citation: Biology of Mood & Anxiety Disorders 2013 3:13

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  25. Content type: Brief Report

    Previous research suggests that individuals with posttraumatic stress disorder (PTSD) preferentially attend to trauma-related emotional stimuli and have difficulty completing unrelated concurrent tasks. Compar...

    Authors: Reid Offringa, Kathryn Handwerger Brohawn, Lindsay K Staples, Stacey J Dubois, Katherine C Hughes, Danielle L Pfaff, Michael B VanElzakker, F Caroline Davis and Lisa M Shin

    Citation: Biology of Mood & Anxiety Disorders 2013 3:10

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  26. Content type: Research

    Generalized social anxiety disorder (gSAD) is associated with a heightened neural sensitivity to signals that convey threat, as evidenced by exaggerated amygdala and/or insula activation when processing face s...

    Authors: Heide Klumpp, David Post, Mike Angstadt, Daniel A Fitzgerald and K Luan Phan

    Citation: Biology of Mood & Anxiety Disorders 2013 3:7

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  27. Content type: Meeting report

    In March, 2012 we held the first Mideast conference on “Depression and Anxiety Spectrum disorders: from basic science to the clinic and back”, at the University of Amman, Jordan. This event brought together bo...

    Authors: Suzanne N Haber, Ziad Safadi and Mohammad R Milad

    Citation: Biology of Mood & Anxiety Disorders 2013 3:6

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  28. Content type: Research

    Social anxiety disorder (SAD) is widely thought to be characterized by heightened behavioral and limbic reactivity to socio-emotional stimuli. However, although behavioral findings are clear, neural findings a...

    Authors: Michal Ziv, Philippe R Goldin, Hooria Jazaieri, Kevin S Hahn and James J Gross

    Citation: Biology of Mood & Anxiety Disorders 2013 3:5

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  29. Content type: Review

    Considerable variation is evident in response to psychological therapies for mood and anxiety disorders. Genetic factors alongside environmental variables and gene-environment interactions are implicated in th...

    Authors: Kathryn J Lester and Thalia C Eley

    Citation: Biology of Mood & Anxiety Disorders 2013 3:4

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  30. Content type: Research

    Recent studies implicate individual differences in regulatory focus as contributing to self-regulatory dysfunction, particularly not responding to positive outcomes. How such individual differences emerge, howeve...

    Authors: Elena L Goetz, Ahmad R Hariri, Diego A Pizzagalli and Timothy J Strauman

    Citation: Biology of Mood & Anxiety Disorders 2013 3:3

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  31. Content type: Research

    Posttraumatic stress disorder (PTSD) is a debilitating anxiety disorder. Surveys of the general population suggest that while 50-85% of Americans will experience a traumatic event in their lifetime, only 2-50%...

    Authors: Julia DiGangi, Guia Guffanti, Katie A McLaughlin and Karestan C Koenen

    Citation: Biology of Mood & Anxiety Disorders 2013 3:2

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  32. Content type: Research

    Recent laboratory studies employing an extended sleep deprivation model have mapped sleep-related changes in behavior onto functional alterations in specific brain regions supporting emotion, suggesting possib...

    Authors: Jared D Minkel, Kristin McNealy, Peter J Gianaros, Emily M Drabant, James J Gross, Stephen B Manuck and Ahmad R Hariri

    Citation: Biology of Mood & Anxiety Disorders 2012 2:22

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  33. Content type: Research

    PTSD is associated with reduction in hippocampal volume and abnormalities in hippocampal function. Hippocampal asymmetry has received less attention, but potentially could indicate lateralised differences in v...

    Authors: Timothy Hall, Cherrie Galletly, C Richard Clark, Melinda Veltmeyer, Linda J Metzger, Mark W Gilbertson, Scott P Orr, Roger K Pitman and Alexander McFarlane

    Citation: Biology of Mood & Anxiety Disorders 2012 2:21

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  34. Content type: Review

    Although the neurobiological mechanisms underlying panic disorder (PD) are not yet clearly understood, increasing amount of evidence from animal and human studies suggests that the amygdala, which plays a pivo...

    Authors: Jieun E Kim, Stephen R Dager and In Kyoon Lyoo

    Citation: Biology of Mood & Anxiety Disorders 2012 2:20

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  35. Content type: Brief Report

    Research into neural mechanisms of drug abuse risk has focused on the role of dysfunction in neural circuits for reward. In contrast, few studies have examined the role of dysfunction in neural circuits of thr...

    Authors: Yuliya S Nikolova and Ahmad R Hariri

    Citation: Biology of Mood & Anxiety Disorders 2012 2:19

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  36. Content type: Review

    Bipolar disorder (BD) is a multi-factorial disorder caused by genetic and environmental influences. It has a large genetic component, with heritability estimated between 59-93%. Recent genome-wide association ...

    Authors: Melanie P Leussis, Jon M Madison and Tracey L Petryshen

    Citation: Biology of Mood & Anxiety Disorders 2012 2:18

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  37. Content type: Research

    Anxiety disorders are characterized by specific emotions, thoughts and physiological responses. Little is known, however, about the relationship between psychological/personality indices of anxiety responses t...

    Authors: Karen G Martínez, Melissa Castro-Couch, José A Franco-Chaves, Brenda Ojeda-Arce, Gustavo Segura, Mohammed R Milad and Gregory J Quirk

    Citation: Biology of Mood & Anxiety Disorders 2012 2:16

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  38. Content type: Research

    Lithium is considered by many as the gold standard medication in the management of bipolar disorder (BD). However, the clinical response to lithium is heterogeneous, and the molecular basis for this difference...

    Authors: Lori Lowthert, Janine Leffert, Aiping Lin, Sheila Umlauf, Kathleen Maloney, Anjana Muralidharan, Boris Lorberg, Shrikant Mane, Hongyu Zhao, Rajita Sinha, Zubin Bhagwagar and Robert Beech

    Citation: Biology of Mood & Anxiety Disorders 2012 2:15

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  39. Content type: Review

    The field of non-pharmacological therapies for treatment resistant depression (TRD) is rapidly evolving and new somatic therapies are valuable options for patients who have failed numerous other treatments. A ...

    Authors: Cristina Cusin and Darin D Dougherty

    Citation: Biology of Mood & Anxiety Disorders 2012 2:14

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    The Erratum to this article has been published in Biology of Mood & Anxiety Disorders 2013 3:1

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