Shin LM, Whalen PJ, Pitman RK, Bush G, Macklin ML, Lasko NB, Orr SP, McInerney SC, Rauch SL: An fMRI study of anterior cingulate function in posttraumatic stress disorder. BiolPsychiatry. 2001, 50: 932-942.
CAS
Google Scholar
Graham BM, Milad MR: The Study of Fear Extinction: Implications for Anxiety Disorders. Am J Psychiatry. 2011, 168: 1255-1265.
Article
PubMed Central
PubMed
Google Scholar
Hettema JM, Kettenmann B, Ahluwalia V, McCarthy C, Kates WR, Schmitt JE, Silberg JL, Neale MC, Kendler KS, Fatouros P: Pilot multimodal twin imaging study of generalized anxiety disorder. Depress Anxiety. 2011, (Epub ahead of print)
Google Scholar
Goldstein JM, Jerram M, Abbs B, Whitfield-Gabrieli S, Makris N: Sex differences in stress response circuitry activation dependent on female hormonal cycle. J Neurosci. 2010, 30: 431-438. 10.1523/JNEUROSCI.3021-09.2010.
Article
PubMed Central
PubMed
Google Scholar
Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS: Faraone SV, Tsuang MT: Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. CerebCortex. 2001, 11: 490-497.
CAS
Google Scholar
Mong JA, Glaser E, McCarthy MM: Gonadal steroids promote glial differentiation and alter neuronal morphology in the developing hypothalamus in a regionally specific manner. J Neurosci. 1999, 19: 1464-1472.
CAS
PubMed
Google Scholar
Arnold AP, Gorski RA: Gonadal steroid induction of structural sex differences in the central nervous system. Annu Rev Neurosci. 1984, 7: 413-442. 10.1146/annurev.ne.07.030184.002213.
Article
CAS
PubMed
Google Scholar
Cahill L, Uncapher M, Kilpatrick L, Alkire MT, Turner J: Sex-related hemispheric lateralization of amygdala function in emotionally influenced memory: an FMRI investigation. LearnMem. 2004, 11: 261-266.
Google Scholar
Canli T, Gabrieli JD: Imaging gender differences in sexual arousal. NatNeurosci. 2004, 7: 325-326.
CAS
Google Scholar
Goldstein JM, Jerram M, Poldrack R, Anagnoson R, Breiter HC, Makris N, Goodman JM, Tsuang MT, Seidman LJ: Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory. Neuropsychology. 2005, 19: 509-519.
Article
PubMed
Google Scholar
Baran SE, Armstrong CE, Niren DC, Hanna JJ, Conrad CD: Chronic stress and sex differences on the recall of fear conditioning and extinction. NeurobiolLearnMem. 2009, 91: 323-332.
Google Scholar
Milad MR, Igoe SA, Lebron-Milad K, Novales JE: Estrous cycle phase and gonadal hormones influence conditioned fear extinction. Neuroscience. 2009, 164: 887-895. 10.1016/j.neuroscience.2009.09.011.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gupta RR, Sen S, Diepenhorst LL, Rudick CN, Maren S: Estrogen modulates sexually dimorphic contextual fear conditioning and hippocampal long-term potentiation (LTP) in rats(1). Brain Res. 2001, 888: 356-365. 10.1016/S0006-8993(00)03116-4.
Article
CAS
PubMed
Google Scholar
Dalla C, Shors TJ: Sex differences in learning processes of classical and operant conditioning. Physiol Behav. 2009, 97: 229-238. 10.1016/j.physbeh.2009.02.035.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ribeiro AM, Barbosa FF, Godinho MR, Fernandes VS, Munguba H, Melo TG, Barbosa MT, Eufrasio RA, Cabral A, Izidio GS, Silva RH: Sex differences in aversive memory in rats: possible role of extinction and reactive emotional factors. Brain Cogn. 2010, 74: 145-151. 10.1016/j.bandc.2010.07.012.
Article
PubMed
Google Scholar
Merz CJ, Tabbert K, Schweckendiek J, Klucken T, Vaitl D, Stark R, Wolf OT: Investigating the impact of sex and cortisol on implicit fear conditioning with fMRI. Psychoneuroendocrinology. 2010, 35: 33-46. 10.1016/j.psyneuen.2009.07.009.
Article
CAS
PubMed
Google Scholar
Milad MR, Goldstein JM, Orr SP, Wedig MM, Klibanski A, Pitman RK, Rauch SL: Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humans. BehavNeurosci. 2006, 120: 1196-1203.
CAS
Google Scholar
Felmingham K, Williams LM, Kemp AH, Liddell B, Falconer E, Peduto A, Bryant R: Neural responses to masked fear faces: sex differences and trauma exposure in posttraumatic stress disorder. J Abnorm Psychol. 2010, 119: 241-247.
Article
PubMed
Google Scholar
Wiltgen BJ, Sanders MJ, Ferguson C, Homanics GE, Fanselow MS: Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAA receptor. LearnMem. 2005, 12: 327-333.
Google Scholar
Zorawski M, Cook CA, Kuhn CM, LaBar KS: Sex, stress, and fear: individual differences in conditioned learning. Cogn Affect Behav Neurosci. 2005, 5: 191-201. 10.3758/CABN.5.2.191.
Article
PubMed
Google Scholar
Maren S, De Oca B, Fanselow MS: Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning. Brain Res. 1994, 661: 25-34. 10.1016/0006-8993(94)91176-2.
Article
CAS
PubMed
Google Scholar
Aguilar R, Gil L, Gray JA, Driscoll P, Flint J, Dawson GR, Gimenez-Llort L, Escorihuela RM, Fernandez-Teruel A, Tobena A: Fearfulness and sex in F2 Roman rats: males display more fear though both sexes share the same fearfulness traits. Physiol Behav. 2003, 78: 723-732. 10.1016/S0031-9384(03)00043-X.
Article
CAS
PubMed
Google Scholar
Milad MR, Zeidan MA, Contero A, Pitman RK, Klibanski A, Rauch SL, Goldstein JM: The influence of gonadal hormones on conditioned fear extinction in healthy humans. Neuroscience. 2010, 168: 652-658. 10.1016/j.neuroscience.2010.04.030.
Article
PubMed Central
CAS
PubMed
Google Scholar
Milad MR, Igoe SA, Lebron-Milad K, Novales JE: Estrous cycle phase and gonadal hormones influence conditioned fear extinction. Neuroscience. 2009, 164: 887-895. 10.1016/j.neuroscience.2009.09.011.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rosenbaum JF, Biederman J, Hirshfeld DR, Bolduc EA, Faraone SV, Kagan J, Snidman N, Reznick JS: Further evidence of an association between behavioral inhibition and anxiety disorders: results from a family study of children from a non-clinical sample. JPsychiatrRes. 1991, 25: 49-65.
CAS
Google Scholar
Goldstein JM, Jerram M, Poldrack R, Ahern T, Kennedy DN, Seidman LJ, Makris N: Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging. JNeurosci. 2005, 25: 9309-9316. 10.1523/JNEUROSCI.2239-05.2005.
Article
CAS
Google Scholar
Protopopescu X, Pan H, Altemus M, Tuescher O, Polanecsky M, McEwen B, Silbersweig D, Stern E: Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle. Proc Natl Acad Sci USA. 2005, 102: 16060-16065. 10.1073/pnas.0502818102.
Article
PubMed Central
CAS
PubMed
Google Scholar
Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL: Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. BiolPsychiatry. 2007, 62: 446-454.
Google Scholar
Uejima A, Amano T, Nomura N, Noro M, Yasue T, Shiroishi T, Ohta K, Yokoyama H, Tamura K: Anterior shift in gene expression precedes anteriormost digit formation in amniote limbs. Dev Growth Differ. 2010, 52: 223-234. 10.1111/j.1440-169X.2009.01161.x.
Article
CAS
PubMed
Google Scholar
Foa EB, Rothbaum BO, Riggs DS, Murdock TB: Treatment of posttraumatic stress disorder in rape victims: a comparison between cognitive-behavioral procedures and counseling. JConsult ClinPsychol. 1991, 59: 715-723.
CAS
Google Scholar
Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, Sanislow C, Wang P: Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010, 167: 748-751. 10.1176/appi.ajp.2010.09091379.
Article
PubMed
Google Scholar
Milad MR, Pitman RK, Ellis CB, Gold AL, Shin LM, Lasko NB, Zeidan MA, Handwerger K, Orr SP, Rauch SL: Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. BiolPsychiatry. 2009, 66: 1075-1082.
Google Scholar
Zeidan MA, Igoe SA, Linnman C, Vitalo A, Levine JB, Klibanski A, Goldstein JM, Milad MR: Estradiol Modulates Medial Prefrontal Cortex and Amygdala Activity During Fear Extinction in Women and Female Rats. Biol Psychiatry. 2011, 70: 920-927. 10.1016/j.biopsych.2011.05.016.
Article
PubMed Central
CAS
PubMed
Google Scholar
First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. 2002, Biometrics Research, New York State Psychiatric Institute, New York
Google Scholar
Milad MR, Pitman RK, Ellis CB, Gold AB, Shin LM, Lasko NB, Handwerger K, Orr SP, Rauch SL: Neurobiological basis for failure to recall extinction memory in Posttraumatic Stress Disorder. BiolPsychiatry. 2009, 66: 1075-1082.
Google Scholar
Milad MR, Orr SP, Pitman RK, Rauch SL: Context modulation of memory for fear extinction in humans. Psychophysiology. 2005, 42: 456-464. 10.1111/j.1469-8986.2005.00302.x.
Article
PubMed
Google Scholar
Orr SP, Metzger LJ, Lasko NB, Macklin ML, Peri T, Pitman RK: De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. JAbnormPsychol. 2000, 109: 290-298.
CAS
Google Scholar
Esclassan F, Coutureau E, Di Scala G, Marchand AR: A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. J Neurosci. 2009, 29: 8087-8093. 10.1523/JNEUROSCI.0543-09.2009.
Article
CAS
PubMed
Google Scholar
Stefanova N, Ovtscharoff W: Sexual dimorphism of the bed nucleus of the stria terminalis and the amygdala. Adv Anat Embryol Cell Biol. 2000, 158 (III-X): 1-78.
Article
Google Scholar
Rougemont-Bucking A, Linnman C, Zeffiro TA, Zeidan MA, Lebron-Milad K, Rodriguez-Romaguera J, Rauch SL, Pitman RK, Milad MR: Altered processing of contextual information during fear extinction in PTSD: an fMRI study. CNS Neurosci Ther. 2011, 17: 227-236. 10.1111/j.1755-5949.2010.00152.x.
Article
PubMed
Google Scholar
Linnman C, Rougemont-Bucking A, Beucke JC, Zeffiro TA, Milad MR: Unconditioned responses and functional fear networks in human classical conditioning. Behav Brain Res. 2011, 221: 237-245. 10.1016/j.bbr.2011.02.045.
Article
PubMed Central
PubMed
Google Scholar
Milad MR, Quirk GJ: Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 2002, 420: 70-74. 10.1038/nature01138.
Article
CAS
PubMed
Google Scholar
Curley JP, Jordan ER, Swaney WT, Izraelit A, Kammel S, Champagne FA: The meaning of weaning: influence of the weaning period on behavioral development in mice. Dev Neurosci. 2009, 31: 318-331. 10.1159/000216543.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nielsen SE, Ertman N, Lakhani YS, Cahill L: Hormonal contraception usage is associated with altered memory for an emotional story. Neurobiol Learn Mem. 2011, 96: 378-384. 10.1016/j.nlm.2011.06.013.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chang YJ, Yang CH, Liang YC, Yeh CM, Huang CC, Hsu KS: Estrogen modulates sexually dimorphic contextual fear extinction in rats through estrogen receptor beta. Hippocampus. 2009, 19: 1142-1150. 10.1002/hipo.20581.
Article
CAS
PubMed
Google Scholar
Milad MR, Quirk GJ, Pitman RK, Orr SP, Fischl B, Rauch SL: A role for the human dorsal anterior cingulate cortex in fear expression. Biol Psychiatry. 2007, 62: 1191-1194. 10.1016/j.biopsych.2007.04.032.
Article
PubMed
Google Scholar
Linnman C, Zeidan MA, Furtak SC, Pitman RK, Quirk GJ, Milad MR: Resting Amygdala and Medial Prefrontal Metabolism Predicts Functional Activation of the Fear Extinction Circuit. Am J Psychiatry. 2012, : -(Epub ahead of print)
Etkin A, Egner T, Kalisch R: Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci. 2011, 15: 85-93. 10.1016/j.tics.2010.11.004.
Article
PubMed Central
PubMed
Google Scholar
Milad MR, Quirk GJ, Pitman RK, Orr SP, Fischl B, Rauch SL: A role for the human dorsal anterior cingulate cortex in fear expression. BiolPsychiatry. 2007, 62: 1191-1194.
Google Scholar
Mobbs D, Marchant JL, Hassabis D, Seymour B, Tan G, Gray M, Petrovic P, Dolan RJ, Frith CD: From threat to fear: the neural organization of defensive fear systems in humans. J Neurosci. 2009, 29: 12236-12243. 10.1523/JNEUROSCI.2378-09.2009.
Article
PubMed Central
CAS
PubMed
Google Scholar
Davis M, Whalen PJ: The amygdala: vigilance and emotion. MolPsychiatry. 2001, 6: 13-34.
CAS
Google Scholar
Quirk GJ, Mueller D: Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology. 2008, 33: 56-72. 10.1038/sj.npp.1301555.
Article
PubMed Central
PubMed
Google Scholar