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Table 3 BOLD responses from both our anatomical ROI analyses and our functional ROI analyses comparing males and women during the different phases of the study

From: Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitry

Bold responses from anatomical ROI analyses

Phase

condition

regions

coordinates

z

P(≤)

conditioning

F > M

L-dACC

−8,38,26

3.54

0.001

  

R-rACC

12,58,4

3.44

0.001

  

Amyg

28,-6,-16

3.08

0.001

 

M > F

non

   

Ext learning

F > M

non

   
 

M > F

non

   

Ext Recall

F > M

L-insula

−46,-2,-10

3.15

0.002

 

M > F

L-rACC

−6,32,-4

2.79

0.005

BOLD responses from functional ROI analyses

Conditioning

F > M

non

   
 

M > F

non

   

Ext Learning

F > M

dACC

8,12,18

3.62

0.001

  

dACC

10,14,20

3.27

0.001

  

mPFC

28,54,-4

3.33

0.001

  

L-hypotha

−8,2,-6

2.25

0.024

 

M < F

hypothalamus

6,4,-6

2.44

0.015

Ext Recall

F > M

non

   
 

M > F

L-rACC

−6,42,-16

3.16

0.001

  1. ROIs are based on sexually dimorphic areas of the stress response circuitry identified by Goldstein and colleagues (2010).