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  1. Coordination of activity between the amygdala and ventromedial prefrontal cortex (vmPFC) is important for fear-extinction learning. Aberrant recruitment of this circuitry is associated with anxiety disorders. ...

    Authors: Jayne Morriss, Anastasia Christakou and Carien M. van Reekum
    Citation: Biology of Mood & Anxiety Disorders 2015 5:4
  2. Post-traumatic stress disorder (PTSD) is accompanied by disturbed sleep and an impaired ability to learn and remember extinction of conditioned fear. Following a traumatic event, the full spectrum of PTSD symp...

    Authors: Edward F. Pace-Schott, Anne Germain and Mohammed R. Milad
    Citation: Biology of Mood & Anxiety Disorders 2015 5:3
  3. Previous research reported that individual differences in the stress response were moderated by an interaction between individuals’ life stress experience and the serotonin transporter-linked polymorphic regio...

    Authors: Elif A Duman and Turhan Canli
    Citation: Biology of Mood & Anxiety Disorders 2015 5:2
  4. There is growing interest in the use of neuroimaging for the direct treatment of mental illness. Here, we present a new framework for such treatment, neurocognitive therapeutics. What distinguishes neurocognit...

    Authors: David M Schnyer, Christopher G Beevers, Megan T deBettencourt, Stephanie M Sherman, Jonathan D Cohen, Kenneth A Norman and Nicholas B Turk-Browne
    Citation: Biology of Mood & Anxiety Disorders 2015 5:1
  5. Obsessive-compulsive disorder (OCD) is a common and debilitating neuropsychiatric illness thought to involve abnormal connectivity of widespread brain networks, including frontal-striatal-thalamic circuits. At...

    Authors: Isabelle M Rosso, Elizabeth A Olson, Jennifer C Britton, S Evelyn Stewart, George Papadimitriou, William DS Killgore, Nikos Makris, Sabine Wilhelm, Michael A Jenike and Scott L Rauch
    Citation: Biology of Mood & Anxiety Disorders 2014 4:13
  6. Childhood onset of anxiety disorders is associated with greater functional impairment and burden across the lifespan. Recent work suggests that generalized anxiety disorder (GAD) is characterized by dysfunctio...

    Authors: Lisa L Hamm, Rachel H Jacobs, Meghan W Johnson, Daniel A Fitzgerald, Kate D Fitzgerald, Scott A Langenecker, Christopher S Monk and K Luan Phan
    Citation: Biology of Mood & Anxiety Disorders 2014 4:15
  7. Aberrant amygdala-prefrontal interactions at rest and during emotion processing are implicated in the pathophysiology of generalized social anxiety disorder (gSAD), a common disorder characterized by fears of ...

    Authors: Heide Klumpp, Michael K Keutmann, Daniel A Fitzgerald, Stewart A Shankman and K Luan Phan
    Citation: Biology of Mood & Anxiety Disorders 2014 4:14
  8. The experience of early life stress is a consistently identified risk factor for the development of mood and anxiety disorders. Preclinical research employing animal models of early life stress has made inroad...

    Authors: Adam X Gorka, Jamie L Hanson, Spenser R Radtke and Ahmad R Hariri
    Citation: Biology of Mood & Anxiety Disorders 2014 4:12
  9. It has long been suggested that feedback signals from facial muscles influence emotional experience. The recent surge in use of botulinum toxin (BTX) to induce temporary muscle paralysis offers a unique opport...

    Authors: M Justin Kim, Maital Neta, F Caroline Davis, Erika J Ruberry, Diana Dinescu, Todd F Heatherton, Mitchell A Stotland and Paul J Whalen
    Citation: Biology of Mood & Anxiety Disorders 2014 4:11
  10. Prior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. However, no study to date has investigated the neural correlates of unpredictable ...

    Authors: Stephanie M Gorka, Brady D Nelson, K Luan Phan and Stewart A Shankman
    Citation: Biology of Mood & Anxiety Disorders 2014 4:9
  11. Scientists are beginning to document abnormalities in white matter connectivity in major depressive disorder (MDD). Recent developments in diffusion-weighted image analyses, including tractography clustering m...

    Authors: Matthew D Sacchet, Gautam Prasad, Lara C Foland-Ross, Shantanu H Joshi, J Paul Hamilton, Paul M Thompson and Ian H Gotlib
    Citation: Biology of Mood & Anxiety Disorders 2014 4:8
  12. Previous functional imaging studies using symptom provocation in patients with social anxiety disorder (SAD) reported inconsistent findings, which might be at least partially related to different time-dependen...

    Authors: Stephanie Boehme, Alexander Mohr, Michael PI Becker, Wolfgang HR Miltner and Thomas Straube
    Citation: Biology of Mood & Anxiety Disorders 2014 4:6
  13. Animal studies have suggested that the hippocampus may play an important role in anxiety as part of the Behavioural Inhibition System (BIS), which mediates reactivity to threat and punishment and can predict a...

    Authors: Liat Levita, Catherine Bois, Andrew Healey, Emily Smyllie, Evelina Papakonstantinou, Tom Hartley and Colin Lever
    Citation: Biology of Mood & Anxiety Disorders 2014 4:4
  14. Premenstrual dysphoric disorder (PMDD), characterized by luteal phase-induced negative affect and loss of impulse control, often results in compromised social interactions. Although amygdala activation is gene...

    Authors: Malin Gingnell, Victoria Ahlstedt, Elin Bannbers, Johan Wikström, Inger Sundström-Poromaa and Mats Fredrikson
    Citation: Biology of Mood & Anxiety Disorders 2014 4:3
  15. Recent studies examining the interaction between the 5-HTTLPR locus in the serotonin transporter gene and life stress in predicting depression have yielded equivocal results, leading some researchers to questi...

    Authors: Christopher C Conway, George M Slavich and Constance Hammen
    Citation: Biology of Mood & Anxiety Disorders 2014 4:2
  16. Corticotropin-releasing factor type 2 receptors (CRFR2) are suggested to facilitate successful recovery from stress to maintain mental health. They are abundant in the midbrain raphe nuclei, where they regulat...

    Authors: Orna Issler, Roderick N Carter, Evan D Paul, Paul AT Kelly, Henry J Olverman, Adi Neufeld-Cohen, Yael Kuperman, Christopher A Lowry, Jonathan R Seckl, Alon Chen and Pauline M Jamieson
    Citation: Biology of Mood & Anxiety Disorders 2014 4:1
  17. Changes in glucocorticoid receptors (GRs) have been implicated in the pathogenesis of stress related psychiatric disorders such as depression and post-traumatic stress disorder (PTSD). Abnormal adaptation of t...

    Authors: Sophie A George, Stephanie A Stout, Melissa Tan, Dayan Knox and Israel Liberzon
    Citation: Biology of Mood & Anxiety Disorders 2013 3:22
  18. Early adverse experiences, especially those involving disruption of the mother-infant relationship, are detrimental for proper socioemotional development in primates. Humans with histories of childhood maltrea...

    Authors: Brittany R Howell, Kai M McCormack, Alison P Grand, Nikki T Sawyer, Xiaodong Zhang, Dario Maestripieri, Xiaoping Hu and Mar M Sanchez
    Citation: Biology of Mood & Anxiety Disorders 2013 3:21
  19. Social anxiety disorder (SAD) is thought to involve deficits in emotion regulation, and more specifically, deficits in cognitive reappraisal. However, evidence for such deficits is mixed.

    Authors: Michal Ziv, Philippe R Goldin, Hooria Jazaieri, Kevin S Hahn and James J Gross
    Citation: Biology of Mood & Anxiety Disorders 2013 3:20
  20. Several mental illnesses, including anxiety, can manifest during development, with onsets in late childhood. Understanding the neurobiological underpinnings of risk for anxiety is of crucial importance for ear...

    Authors: Tanja Jovanovic, Karin Maria Nylocks and Kaitlyn L Gamwell
    Citation: Biology of Mood & Anxiety Disorders 2013 3:17
  21. Extinction learning is proposed to be one key mechanism of action underlying exposure-based cognitive-behavioral therapy (CBT) in specific phobia. Beyond that, cognitive reappraisal, one important strategy to ...

    Authors: Andrea Hermann, Verena Leutgeb, Wilfried Scharmüller, Dieter Vaitl, Anne Schienle and Rudolf Stark
    Citation: Biology of Mood & Anxiety Disorders 2013 3:16
  22. Although several psychological and pharmacological treatment options are available for anxiety disorders, not all patients respond well to each option. Furthermore, given the relatively long duration of adequa...

    Authors: Lisa M Shin, F Caroline Davis, Michael B VanElzakker, Mary K Dahlgren and Stacey J Dubois
    Citation: Biology of Mood & Anxiety Disorders 2013 3:15
  23. Social Anxiety Disorder (SAD) is a common and debilitating condition that typically manifests in adolescence. Here we describe cognitive factors engaged by brain-imaging tasks, which model the peer-based socia...

    Authors: Johanna M Jarcho, Ellen Leibenluft, Olga Lydia Walker, Nathan A Fox, Daniel S Pine and Eric E Nelson
    Citation: Biology of Mood & Anxiety Disorders 2013 3:14
  24. Various neuropsychiatric conditions, including posttraumatic stress disorder (PTSD), are characterized by deficient fear extinction, but individuals differ greatly in risk for these. While there is growing evi...

    Authors: Kathryn MacPherson, Nigel Whittle, Marguerite Camp, Ozge Gunduz-Cinar, Nicolas Singewald and Andrew Holmes
    Citation: Biology of Mood & Anxiety Disorders 2013 3:13
  25. Previous research suggests that individuals with posttraumatic stress disorder (PTSD) preferentially attend to trauma-related emotional stimuli and have difficulty completing unrelated concurrent tasks. Compar...

    Authors: Reid Offringa, Kathryn Handwerger Brohawn, Lindsay K Staples, Stacey J Dubois, Katherine C Hughes, Danielle L Pfaff, Michael B VanElzakker, F Caroline Davis and Lisa M Shin
    Citation: Biology of Mood & Anxiety Disorders 2013 3:10
  26. Generalized social anxiety disorder (gSAD) is associated with a heightened neural sensitivity to signals that convey threat, as evidenced by exaggerated amygdala and/or insula activation when processing face s...

    Authors: Heide Klumpp, David Post, Mike Angstadt, Daniel A Fitzgerald and K Luan Phan
    Citation: Biology of Mood & Anxiety Disorders 2013 3:7
  27. In March, 2012 we held the first Mideast conference on “Depression and Anxiety Spectrum disorders: from basic science to the clinic and back”, at the University of Amman, Jordan. This event brought together bo...

    Authors: Suzanne N Haber, Ziad Safadi and Mohammad R Milad
    Citation: Biology of Mood & Anxiety Disorders 2013 3:6
  28. Social anxiety disorder (SAD) is widely thought to be characterized by heightened behavioral and limbic reactivity to socio-emotional stimuli. However, although behavioral findings are clear, neural findings a...

    Authors: Michal Ziv, Philippe R Goldin, Hooria Jazaieri, Kevin S Hahn and James J Gross
    Citation: Biology of Mood & Anxiety Disorders 2013 3:5
  29. Considerable variation is evident in response to psychological therapies for mood and anxiety disorders. Genetic factors alongside environmental variables and gene-environment interactions are implicated in th...

    Authors: Kathryn J Lester and Thalia C Eley
    Citation: Biology of Mood & Anxiety Disorders 2013 3:4
  30. Recent studies implicate individual differences in regulatory focus as contributing to self-regulatory dysfunction, particularly not responding to positive outcomes. How such individual differences emerge, howeve...

    Authors: Elena L Goetz, Ahmad R Hariri, Diego A Pizzagalli and Timothy J Strauman
    Citation: Biology of Mood & Anxiety Disorders 2013 3:3
  31. Posttraumatic stress disorder (PTSD) is a debilitating anxiety disorder. Surveys of the general population suggest that while 50-85% of Americans will experience a traumatic event in their lifetime, only 2-50%...

    Authors: Julia DiGangi, Guia Guffanti, Katie A McLaughlin and Karestan C Koenen
    Citation: Biology of Mood & Anxiety Disorders 2013 3:2
  32. Recent laboratory studies employing an extended sleep deprivation model have mapped sleep-related changes in behavior onto functional alterations in specific brain regions supporting emotion, suggesting possib...

    Authors: Jared D Minkel, Kristin McNealy, Peter J Gianaros, Emily M Drabant, James J Gross, Stephen B Manuck and Ahmad R Hariri
    Citation: Biology of Mood & Anxiety Disorders 2012 2:22
  33. PTSD is associated with reduction in hippocampal volume and abnormalities in hippocampal function. Hippocampal asymmetry has received less attention, but potentially could indicate lateralised differences in v...

    Authors: Timothy Hall, Cherrie Galletly, C Richard Clark, Melinda Veltmeyer, Linda J Metzger, Mark W Gilbertson, Scott P Orr, Roger K Pitman and Alexander McFarlane
    Citation: Biology of Mood & Anxiety Disorders 2012 2:21
  34. Although the neurobiological mechanisms underlying panic disorder (PD) are not yet clearly understood, increasing amount of evidence from animal and human studies suggests that the amygdala, which plays a pivo...

    Authors: Jieun E Kim, Stephen R Dager and In Kyoon Lyoo
    Citation: Biology of Mood & Anxiety Disorders 2012 2:20
  35. Research into neural mechanisms of drug abuse risk has focused on the role of dysfunction in neural circuits for reward. In contrast, few studies have examined the role of dysfunction in neural circuits of thr...

    Authors: Yuliya S Nikolova and Ahmad R Hariri
    Citation: Biology of Mood & Anxiety Disorders 2012 2:19
  36. Bipolar disorder (BD) is a multi-factorial disorder caused by genetic and environmental influences. It has a large genetic component, with heritability estimated between 59-93%. Recent genome-wide association ...

    Authors: Melanie P Leussis, Jon M Madison and Tracey L Petryshen
    Citation: Biology of Mood & Anxiety Disorders 2012 2:18
  37. Anxiety disorders are characterized by specific emotions, thoughts and physiological responses. Little is known, however, about the relationship between psychological/personality indices of anxiety responses t...

    Authors: Karen G Martínez, Melissa Castro-Couch, José A Franco-Chaves, Brenda Ojeda-Arce, Gustavo Segura, Mohammed R Milad and Gregory J Quirk
    Citation: Biology of Mood & Anxiety Disorders 2012 2:16
  38. Lithium is considered by many as the gold standard medication in the management of bipolar disorder (BD). However, the clinical response to lithium is heterogeneous, and the molecular basis for this difference...

    Authors: Lori Lowthert, Janine Leffert, Aiping Lin, Sheila Umlauf, Kathleen Maloney, Anjana Muralidharan, Boris Lorberg, Shrikant Mane, Hongyu Zhao, Rajita Sinha, Zubin Bhagwagar and Robert Beech
    Citation: Biology of Mood & Anxiety Disorders 2012 2:15
  39. The field of non-pharmacological therapies for treatment resistant depression (TRD) is rapidly evolving and new somatic therapies are valuable options for patients who have failed numerous other treatments. A ...

    Authors: Cristina Cusin and Darin D Dougherty
    Citation: Biology of Mood & Anxiety Disorders 2012 2:14

    The Erratum to this article has been published in Biology of Mood & Anxiety Disorders 2013 3:1