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Table 2 Significant activation patterns in a priori regions of interest and other brain regions during extinction

From: Intolerance of uncertainty predicts fear extinction in amygdala-ventromedial prefrontal cortical circuitry

Extinction Brain region BA Voxels (mm3) Max Z Location of max Z
x y z
A priori regions        
 (CS+ > CS−)early > (CS+ > CS−)late × IU R amygdala   33 2.96 26 −8 −12
 (CS− > CS+)early > (CS− > CS+)late × IU R L vmPFC 10 40 2.92 −8 42 −16
Outside a priori regions        
 CS+ > CS− L lateral occipital cortex, inferior parietal lobule 7/39 439 3.31 −38 −60 44
 (CS+ > CS−)early > (CS+ > CS−)late R occipital pole 18 643 3.88 34 −94 2
 (CS− > CS+)early > (CS− > CS+)late R precentral gyrus, postcentral gyrus 3–4/6 504 3.49 38 −24 38
 (CS− > CS+)early > (CS− > CS+)late × IU Cingulate gyrus, juxtapositional lobule, precentral gyrus, postcentral gyrus, parietal lobule 3–7/40 4267 3.99 −2 −8 60
 (CS− > CS+)early > (CS− > CS+)late × IU R central opercular cortex 6 361 3.16 56 −2 6
 (CS− > CS+)early > (CS− > CS+)late × IU L parietal operculum cortex 40 304 3.16 −52 −28 14
 (CS− > CS+)early > (CS− > CS+)late × IU R parietal operculum cortex 40 292 3.33 56 −26 18
 (CS− > CS+)early > (CS− > CS+)late × IU L cerebellum   274 3.29 12 −70 −18
 (CS− > CS+)early > (CS− > CS+)late × IU R lateral occipital cortex 37 259 3.23 46 −60 −8
  1. Note: clusters for small volume corrected a priori regions and whole-brain corrected regions outside a priori regions corrected for multiple comparisons at p < 0.05. Location of cluster’s maximum Z are in MNI space. BA Brodmann areas, R right, L left