Intolerance of uncertainty predicts fear extinction in amygdala-ventromedial prefrontal cortical circuitry

Table 2 Significant activation patterns in a priori regions of interest and other brain regions during extinction

Extinction	Brain region	BA	Voxels (mm³)	Max Z	Location of max Z
Extinction	Brain region	BA	Voxels (mm³)	Max Z	x	y	z
A priori regions
(CS+ > CS−)_early > (CS+ > CS−)_late × IU	R amygdala		33	2.96	26	−8	−12
(CS− > CS+)_early > (CS− > CS+)_late × IU	R L vmPFC	10	40	2.92	−8	42	−16
Outside a priori regions
CS+ > CS−	L lateral occipital cortex, inferior parietal lobule	7/39	439	3.31	−38	−60	44
(CS+ > CS−)_early > (CS+ > CS−)_late	R occipital pole	18	643	3.88	34	−94	2
(CS− > CS+)_early > (CS− > CS+)_late	R precentral gyrus, postcentral gyrus	3–4/6	504	3.49	38	−24	38
(CS− > CS+)_early > (CS− > CS+)_late × IU	Cingulate gyrus, juxtapositional lobule, precentral gyrus, postcentral gyrus, parietal lobule	3–7/40	4267	3.99	−2	−8	60
(CS− > CS+)_early > (CS− > CS+)_late × IU	R central opercular cortex	6	361	3.16	56	−2	6
(CS− > CS+)_early > (CS− > CS+)_late × IU	L parietal operculum cortex	40	304	3.16	−52	−28	14
(CS− > CS+)_early > (CS− > CS+)_late × IU	R parietal operculum cortex	40	292	3.33	56	−26	18
(CS− > CS+)_early > (CS− > CS+)_late × IU	L cerebellum		274	3.29	12	−70	−18
(CS− > CS+)_early > (CS− > CS+)_late × IU	R lateral occipital cortex	37	259	3.23	46	−60	−8

Note: clusters for small volume corrected a priori regions and whole-brain corrected regions outside a priori regions corrected for multiple comparisons at p < 0.05. Location of cluster’s maximum Z are in MNI space. BA Brodmann areas, R right, L left

ISSN: 2045-5380