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Figure 2 | Biology of Mood & Anxiety Disorders

Figure 2

From: Neurocognitive therapeutics: from concept to application in the treatment of negative attention bias

Figure 2

Preliminary results of feasibility study. Upper left panel graph shows BDI scores pre and post training and at three 1-week follow-ups (FUW1, FUW2, and FUW3). Lower left panel shows that changes in performance accuracy (indexed by d′ - a statistic that is calculated from hit and false alarm rates and hence reflects detection sensitivity) during training were associated with changes in BDI across this 4-week period. Mean d′ and standard deviation for performance across the 3 days were 1.06(.718), 1.32(.720), and 1.59(.871), respectively. The right panel shows the attention control network that was tested for pre-post changes in resting-state connectivity. This network was identified in previous work as associated with attention control and amenable to change with behavioral training [6]. All participants showed increased connectivity between right middle frontal gyrus (MFG) and bilateral supramarginal gyrus (SMG) of the parietal lobe. The mean and standard deviation in connectivity between right MFG and left SMG pre and post training were 0.11(0.18) and 0.38(0.26), respectively; between right MFG and right SMG 0.17(0.22) and 0.41(0.26), respectively. BA, Brodmann’s area; BDI, Beck Depression Inventory.

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