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Figure 3 | Biology of Mood & Anxiety Disorders

Figure 3

From: Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas

Figure 3

CRFR2-null mice exhibit increased anxiety-like behaviour 48 hours after ARS in the OF test. Under basal conditions (A), immediately following ARS (B), or after CVMS (C), no differences were observed in behaviour between CRFR2-null mice and controls. However, when CVMS mice (D) or naïve mice (E) were exposed to ARS and tested 24 to 48 h later, CRFR2-null mice showed increased anxiety-like behaviour compared with control mice. Data expressed as mean ± SEM. N = 10 to 14 for A-D, N = 5 to 8 for E. *P < 0.05, **P < 0.01, ***P < 0.001, ~P = 0.085, compared with control.

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