Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder

Waugh, Christian E; Hamilton, J Paul; Chen, Michael C; Joormann, Jutta; Gotlib, Ian H

doi:10.1186/2045-5380-2-11

Biology of Mood & Anxiety Disorders

Table 6 Change-point analysis of the interaction of depression and social anxiety in BOLD responses to the social evaluative threat task

From: Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder

Region	x	y	z	voxels	vol (mm³)	Peak t	change-point onset	change-point offset	Control	Depression	Social Anxiety	Co-morbid
Comorbid and/or Control > Depression and/or Social Anxiety
Instructions
l. Parahippocampal G	−40	−38	−2	34	918	7.3	65	82	2.52^b	−6.09^a	−8.17^a	−1.43^ab
l. Insula	−40	4	−2	28	756	6.84	64	69	7.10^c	−8.56^a	−5.08^ab	−0.16^b
l. Insula	−38	−16	8	15	405	5.77	70	78	3.26^b	−6.15^a	−6.46^a	−2.08^ab
l. Insula	−40	−8	20	195	5265	8.47	64	79	2.25^b	−9.35^a	−9.24^a	−4.41^a
r. Insula*	50	−14	14	30	810	5.78	65	71	2.56^b	−7.62^a	−7.50^a	1.00^b
l. Precentral G.	−38	8	22	15	405	5.99	65	75	0.03^b	−4.14^ab	−6.87^a	0.26^b
Early Speech Prep
l. Insula	−50	−34	22	36	972	5.89	115	121	9.46^c	−11.72^a	−1.47^b	2.00^b
Late Speech Prep
l. Lentiform Nucleus	−32	4	−2	15	405	5.58	148	157	3.51^b	−3.26^a	−3.48^a	1.39^ab
Recovery
l. Middle Temporal G.*	−44	−38	2	36	972	7.3	160	170	4.01^b	−7.12^a	−6.40^a	2.08^b
l. Precentral G.	−38	−14	32	23	621	7.07	164	177	4.36^b	−8.80^a	−4.96^a	−3.08^a
Depression and/or Social Anxiety > Comorbid and/or Control
Instructions
Cerebellum: Declive*	8	−62	−20	14	378	−5.38	90	95	−7.42^a	10.43^c	26.22^d	2.94^b
Cuneus*	−8	−68	4	446	12042	−7.94	65	84	3.28^a	27.79^c	29.39^c	12.44^b
r. Inferior Frontal G.	40	20	−10	15	405	−6.07	69	81	−11.20^a	7.13^c	−4.78^b	−8.58^ab
r. Insula	40	4	−4	23	621	−6.57	71	84	−11.09^a	8.04^b	−7.03^a	−7.09^a
r. Cuneus*	22	−76	8	37	999	−6.06	67	79	−1.70^a	15.35^b	21.56^c	3.66^a
Early Speech Prep
No suprathreshold voxels
Late Speech Prep
No suprathreshold voxels
Recovery
Lingual G.	8	−56	−4	448	12096	−7.4	161	172	−3.95^a	27.24^c	18.43^bc	16.44^b
Precuneus*	−2	−68	26	21	567	−6.21	164	171	−6.24^a	24.31^c	23.38^c	12.11^b

Note. These clusters were masked with the clusters that exhibited group average activation differences during the social evaluative threat task. vol = volume; G. = Gyrus. Different subscripts represent significantly differences between the groups, calculated using simple slopes analyses on the beta coefficients (presented here) from the multiple regression models.
* Those regions for which comorbid participants’ activation significantly differed from both pure depression and pure social anxiety groups.

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ISSN: 2045-5380

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