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Table 3 Univariate analysis results

From: An fMRI study of unconditioned responses in post-traumatic stress disorder

Contrast
ROIa 		MNIb, peak x, y, z Z-score Size, voxels Cluster Pvalue, FWEc Region
US d      
   PTSDe > TENCf      
Whole brain -22, 0, -6 5.51 111 < 0.0001 Left putamen
  (-24, 10, -14) -5.47    
  (-32, 2, -4) -4.93    
  18, 10 -12 5.47 90 < 0.0001 Right putamen
  (20, 10, -4) -5.13    
  -22, -4, 48 5.25 19 0.003 Left middle frontal gyrus
  -18, -38, -4 5.07 11 0.007 Left parahippocampal gyrus
Putamen 16, 12, -10 5.34 359 < 0.0001 Right ventral putamen
  (30, -20, 6) -3.79    
  (28, -2, -6) -3.73    
  -26, 2, -4 5.11 840 < 0.0001 Left putamen
  (-22, 8, -10) -4.88    
  (-32, -12, -6) -4.75    
Amygdala -22, 6, -16 4.3 48 0.01 Left amygdala
  24, 2, -16 4.27 81 0.005 Right amygdala
Hippocampus -18, -32, 4 4.43 36 0.029 Left hippocampus
  (-22, -24, -8) -3.74    
  -26, -34, 8 3.79 18 0.028 Left hippocampus
  (-14, -32, 10) -3.52    
  -26, -12, -12 3.69 25 0.042 Left hippocampus
  (-20, -4, 12) -3.62    
Cingulate 8, 12, 42 3.8 19 0.013 Right dorsal acc
Insula 34, -20, 4 4.97 36 0.006 Right posterior insula
  -26, 14, -16 5.05 28 0.008 Left piriform insula
  -34, -6, 16 4.14 13 0.017 Left middle insula
  -36, -22, 4 4.08 17 0.014 Left posterior insula
Caudate -14, 16, -8 4.2 67 0.006 Right caudate
  (16, 18, 0) -3.81    
  16, 0, 16 3.86 24 0.021 Right caudate
  -12, 10, 14 4.41 297 0.001 Left caudate body
  (-18, -2, 22) -4.16    
   TENC > PTSD No significant differences in whole brain or ROI  
Omitted US      
   PTSD > TENC      
Whole brain No significant differences in whole brain  
Hippocampus 22, -10, -20 3.77 54 0.009 Right anterior hippocampus
  (30, -10, -18) -3.46    
   TENC > PTSD No significant differences in whole brain or ROI  
US minus omitted US      
   PTSD > TENC      
Whole brain No significant differences in whole brain  
Putamen 20, 12, -10 3.89 69 0.003 Right ventral putamen
  20, 0, 12 3.48 13 0.032  
Insula -28, 16, -18 4.05 52 0.016 Left orbital insula
  1. Clusters are in bold, with sub-peaks in brackets.
  2. aRegion of interest
  3. bMontreal Neurological Institute.
  4. cFamily-wise error.
  5. dUS, unconditioned stimulus
  6. ePost-traumatic stress disorder.
  7. fTrauma-exposed normal control.
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Biology of Mood & Anxiety Disorders

ISSN: 2045-5380

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