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Table 3 Univariate analysis results

From: An fMRI study of unconditioned responses in post-traumatic stress disorder

Contrast

ROIa

MNIb, peak x, y, z

Z-score

Size, voxels

Cluster Pvalue, FWEc

Region

US d

     

   PTSDe > TENCf

     

Whole brain

-22, 0, -6

5.51

111

< 0.0001

Left putamen

 

(-24, 10, -14)

-5.47

   
 

(-32, 2, -4)

-4.93

   
 

18, 10 -12

5.47

90

< 0.0001

Right putamen

 

(20, 10, -4)

-5.13

   
 

-22, -4, 48

5.25

19

0.003

Left middle frontal gyrus

 

-18, -38, -4

5.07

11

0.007

Left parahippocampal gyrus

Putamen

16, 12, -10

5.34

359

< 0.0001

Right ventral putamen

 

(30, -20, 6)

-3.79

   
 

(28, -2, -6)

-3.73

   
 

-26, 2, -4

5.11

840

< 0.0001

Left putamen

 

(-22, 8, -10)

-4.88

   
 

(-32, -12, -6)

-4.75

   

Amygdala

-22, 6, -16

4.3

48

0.01

Left amygdala

 

24, 2, -16

4.27

81

0.005

Right amygdala

Hippocampus

-18, -32, 4

4.43

36

0.029

Left hippocampus

 

(-22, -24, -8)

-3.74

   
 

-26, -34, 8

3.79

18

0.028

Left hippocampus

 

(-14, -32, 10)

-3.52

   
 

-26, -12, -12

3.69

25

0.042

Left hippocampus

 

(-20, -4, 12)

-3.62

   

Cingulate

8, 12, 42

3.8

19

0.013

Right dorsal acc

Insula

34, -20, 4

4.97

36

0.006

Right posterior insula

 

-26, 14, -16

5.05

28

0.008

Left piriform insula

 

-34, -6, 16

4.14

13

0.017

Left middle insula

 

-36, -22, 4

4.08

17

0.014

Left posterior insula

Caudate

-14, 16, -8

4.2

67

0.006

Right caudate

 

(16, 18, 0)

-3.81

   
 

16, 0, 16

3.86

24

0.021

Right caudate

 

-12, 10, 14

4.41

297

0.001

Left caudate body

 

(-18, -2, 22)

-4.16

   

   TENC > PTSD

No significant differences in whole brain or ROI

 

Omitted US

     

   PTSD > TENC

     

Whole brain

No significant differences in whole brain

 

Hippocampus

22, -10, -20

3.77

54

0.009

Right anterior hippocampus

 

(30, -10, -18)

-3.46

   

   TENC > PTSD

No significant differences in whole brain or ROI

 

US minus omitted US

     

   PTSD > TENC

     

Whole brain

No significant differences in whole brain

 

Putamen

20, 12, -10

3.89

69

0.003

Right ventral putamen

 

20, 0, 12

3.48

13

0.032

 

Insula

-28, 16, -18

4.05

52

0.016

Left orbital insula

  1. Clusters are in bold, with sub-peaks in brackets.
  2. aRegion of interest
  3. bMontreal Neurological Institute.
  4. cFamily-wise error.
  5. dUS, unconditioned stimulus
  6. ePost-traumatic stress disorder.
  7. fTrauma-exposed normal control.