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Table 4 Summary of the studies which included P300 component

From: Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis

Study Study Groups Paradigm Findings
[17] 20 Israeli combat veterans with PTSD
20 without PTSD
Modified target detection visual oddball paradigm, trauma related
non-related
neutral stimuli
Accentuated P300 amplitudes to target stimuli in both controls and PTSD patients
Enhanced P300 amplitude in response to non-target combat related pictures in PTSD group
Prolonged P300 latencies and reaction times to target stimuli were prolonged in PTSD subjects
Increased latency in response to trauma-related stimuli in PTSD subjects
[50] 20 Israeli veterans with PTSD
20 without PTSD
Modified target detection visual oddball paradigm, trauma related,
unrelated, neutral pictures
Smaller response to non-target images in the control, but equal responses to both target and non-target stimuli in the PTSD group
No group difference for the target stimuli, but larger response to the non-target in the PTSD group.
P300 could correctly classify 90% of PTSD and 90% of non-PTSD subjects.
Increased latency of P300 response to combat-related images in relation with the severity of intrusive symptoms.
This relation was negative between the P300 latency and severity of avoidance.
[58] 20 PTSD combat veterans
20 non-PTSD combat veterans
Target detection oddball, traumatic/neutral stimuli Larger P300 amplitude in the PTSD group
No difference inP300 amplitude between the target and non-target in the PTSD group; higher amplitude in response to the target stimuli in the control group.
Earlier and 5 times greater P300 response to combat related pictures in PTSD patients.
Repeated combat related pictures resulted in a rapid P300 amplitude reduction and latency prolongation. This effect was not observed for the target stimuli.
[59] 19 civil PTSD
17 subjects with numerous life events
18 without life events
Auditory oddball Longer reaction times and lower amplitude P300 response
[60] 8 PTSD
8 non-PTSD combat veterans
Visual presentation of a sequence of trauma related and unrelated words Newly identified P300tr component was suppressed to all stimuli in PTSD subjects
[43] 34 PTSD [25 male veterans/9 female victims of rape]
18 non-PTSD [10/8 from the same groups]
Auditory three-tone oddball Smaller P300 response to the target tone. For women group, it was also smaller in response to the distracter tones.
[41] 9 PTSD [assault, rape, MVA, combat]
10 healthy controls
Modified stroop paradigm, visual presentation of neutral, positive and negative words Smaller P300 amplitude to neutral, positive, and negative words in PTSD patients.
Smaller response to neutral words as compared to positive and negative words.
[56] 16 medicated PTSD
9 un-medicated PTSD
10 healthy veterans
Auditory three-tone oddball Significant decrease in P300 at Pz electrode in un-medicated PTSD group compared to the medicated PTSD and healthy subjects.
Subjects with co-morbid panic disorder had the largest P300 amplitudes.
[39] 11 survivors of a ship fire with PTSD or near PTSD
9 controls with other psychiatric illnesses from the same ship
Auditory word and non-word oddball Reduced P300 amplitude to non-words and negative words
[61] 25 combat veterans with PTSD/14 without PTSD Auditory three-tone oddball Reduced P300 amplitude to the target stimuli.
Significant P300 amplitude enhancements at frontal sites to distracting stimuli during the novelty but not during the three-tone oddball tasks.
[62] 10 Vietnam war veterans with PTSD
10 without PTSD
Two oddball tasks of visual trauma-relevant and trauma-irrelevant threat (combat, social-threat, household, and neutral words) Attenuated P300 response to neutral target stimuli
Increased P300 amplitude in response to trauma-relevant combat stimuli but not to trauma-irrelevant social-threat stimuli at frontal electrode sites.
[28] 17 civil PTSD
17 healthy controls
Auditory oddball Smaller P300 in PTSD, later at Pz
[32] 29 PTSD nurse veterans
38 non-PTSD
Three-tone oddball Larger target P300 amplitudes in PTSD subjects
[38] 15 civil PTSD
15 controls
20 angry and 20 neutral faces Slower P270 in the PTSD at occipital electrodes
[63] 25 combat PTSD
15 combat-exposed healthy controls
Three conditioned novelty visual and auditory oddball No significant differences in P300 amplitude or latency regardless of stimulus type (target, novel) or modality (auditory, visual).
[35] 10 civil PTSD
10 controls
Auditory oddball Same P3a amplitude in both groups, but there was a significant post-treatment attenuation of P3a in the PTSD group.
[64] 8 PTSD victims of Tokyo sarin attack
13 healthy controls
Auditory oddball No difference in P300 latency.
Significantly smaller P300 amplitudes in subjects with PTSD.
[65] 33 civil PTSD
33 matched controls
Auditory standard two-tone oddball Delayed reduced P300 target amplitude, coupled with slower and less accurate target detection
[12] 10 male police/veteran PTSD
10 healthy controls
Auditory oddball Smaller P550;
More false negatives and positives;
The higher the anxiety and depression level, the lower the amplitude;
Reverse relationship between the P550 amplitude and intrusions.
[42] 19 PTSD
99 Alcohol dependence
16 personality disorder
25 anxiety or mood disorder
Visual presentation of happy, sad, and neutral faces Longer P300 latency to happy stimuli in midline, central, and right frontal leads;
Reduced P300 amplitude in response to neutral faces.
[40] 16 civil PTSD
15 trauma-exposed without PTSD
16 healthy controls
Modified auditory S1-S2 paradigm Increased P300 and late positive complex amplitudes to trauma-specific questions;
Only the PTSD group showed a differentiation between trauma-specific and neutral questions with respect to P300.
[66] 14 PTSD survivors of an air show disaster
15 trauma-exposed subjects without PTSD
15 healthy controls
Visual differential conditioning paradigm with traumatic/neutral pictures Trauma-exposed subjects with and without PTSD showed successful differential conditioning to the trauma-relevant cue indicative of second-order conditioning
[57] 16 civil PTSD
16 schizophrenia
16 control subjects
Auditory oddball Reduced amplitude of target and non-target P300 responses.
Larger reduction in target P300 amplitude in left posterior parietal leads in PTSD group.
[49] 37 combat exposed veterans with PTSD and 47 without PTSD and their twins Auditory oddball No difference in P300 amplitude; When assessed the un-medicated nonsmoker group separately, P300 amplitude was smaller in the PTSD group
[1] 20 un-medicated and 14 medicated PTSD [mixed etiology]
136 controls
1-back working memory task Reduced P300 working memory amplitude and delayed target P300 in PTSD.
Amplitude reduction and delay of target P300 in medicated PTSD subjects.
Little difference between the non-medicated PTSD subgroup and the controls.
[34] 12 PTSD and 12 control survivors of earthquake Subliminal visual presentation of earthquake-related/unrelated words Increased P2 and P3 amplitude in the PTSD group in response to the trauma-related stimuli