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Table 1 Studies examining the P50 and sensory gating

From: Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis

Study Subjects Paradigm Results
[51] 46 prisoners of war
36 healthy controls
Checkerboard reversal (visual) Significantly greater P50 amplitude and latency
[52] 10 inpatient combat PTSD
5 inpatient alcohol-dependents
5 combat-exposed and
5 combat-non-exposed
healthy subjects
Paired click Diminished P50 habituation in PTSD
[25] 13 female with sexual assault PTSD 16 healthy controls Auditory oddball No difference in P50 peak amplitude and latency
[53] 15 combat veterans
12 healthy control
Paired click P50 amplitude in response to the conditioning stimulus did not differ. P50 T/C ratio was increased in PTSD subjects.
[54] 10 male veteran PTSD + 9 female rape victims matched control groups Paired click Decreased P50 gating
[32] 29 PTSD nurse veterans
38 non-PTSD
Paired click Reduced P50 suppression associated with increased severity of general psychopathology, but not with PTSD.
[27] 12 urban violence PTSD/24 healthy subjects/12 schizophrenics Paired click Higher P50 ratios in subjects with PTSD
[55] 27 civilian with mixed types of trauma and 24 control subjects Paired click Impaired P50 suppression in PTSD subjects
[26] Seven combat veterans with PTSD and 11 matched controls Paired click Impaired M50 gating in the right hemisphere in PTSD subjects. Thinner right STG (Superior Temporal Gyrus) cortical thickness was associated with worse right sensory gating in the PTSD group. The right S1 P50 source strength and gating ratio were correlated with PTSD symptomatology.