Frontostriatal functional connectivity in major depressive disorder

Table 1 Between-group differences in striatal connectivity

Seed	Contrast	Region	Peak voxel (Talairach)			Cluster size	Peak t value
			x	y	z
VS	CTL > MDD	Left subgenual ACC, medial orbitofrontal cortex	-13	41	-4	40	3.9
	MDD > CTL	Left precuneus, posterior cingulate cortex	-7	-46	32	39	4.1
		Right cerebellum	29	-25	-28	31	4.4
		Right inferior parietal lobule	35	-49	38	30	3.9
DC	CTL > MDD	Left medial frontal gyrus	-7	53	-1	32	3.6
	MDD > CTL	Right middle frontal gyrus	32	32	26	44	4.0
VRP	CTL > MDD	Left superior temporal gyrus	-58	-13	-1	93	4.2
		Left medial frontal gyrus, orbitofrontal cortex	-16	35	-10	78	4.5
		Right posterior insula	44	-13	8	30	4.0
	MDD > CTL	Right caudate body, subgyral	17	14	20	52	4.4
DCP	CTL > MDD	Left superior temporal gyrus	-55	2	-7	50	5.1
		Right superior temporal gyrus	53	5	-10	46	4.6
		Right posterior insula	41	-16	11	44	4.4
		Right middle temporal gyrus	53	-64	14	41	3.8
	MDD > CTL	Left inferior parietal lobule, postcentral gyrus	-46	-37	50	80	4.8
		Right inferior parietal lobule	41	-46	47	54	4.7
		Right lingual gyrus	26	-85	-13	38	4.4

Voxel-wise p < 0.005, minimum cluster size = 26 voxels.
ACC = anterior cingulate cortex; CTL = control; DC = dorsal caudate; DCP = dorsal caudal putamen; MDD = major depressive disorder; VRP = ventral rostral putamen; VS = ventral striatum.

ISSN: 2045-5380