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Table 2 Whole-brain results for the valence-by-group analysis of variance during the unpredictable and predictable conditions

From: Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression

Model

Region

MNI coordinates

Voxels

Z-score

 

X

Y

Z

  

Group by valence interaction

     

 U conditions

R medial frontal gyrus

14

-16

58

157

3.80

 

L insula

-36

-2

18

1,162

3.78

 

R insula

34

-20

20

315

3.48

 P conditions

L medial frontal gyrus

-16

-4

54

136

3.72

 

R inferior frontal lobe

2

0

-18

456

3.57

 

L parietal lobe

-28

-42

42

292

3.53

 

L inferior temporal lobe

-46

-54

-10

413

3.44

 

L posterior cingulate cortex

-8

-40

34

198

3.05

Main effect of group

     

 U conditions

L cerebellum

-20

-84

-32

118

3.15

 P conditions

L lingual gyrus

-18

-80

-4

223

4.05

Main effect of valence

     

 U conditions

R middle frontal gyrus

54

18

40

6,501

5.48

 

R inferior frontal gyrus

36

22

-18

23,489

5.13

 

L middle frontal gyrus

-42

6

58

5,435

4.48

 

R medial frontal gyrus

6

44

42

669

4.31

 

R cuneus

4

-98

6

221

3.27

 P conditions

R frontal lobe

22

-4

28

138

3.32

 

R cerebellum

24

-50

-38

67

3.16

  1. Note. Reporting of all clusters exhibiting significance at p < 0.05 (corrected). L left, R right, MNI Montreal Neurologic Institute, U conditions anticipation of unpredictable negative and neutral images, P conditions anticipation of predictable negative and neutral images.