Daily stress reactivity and serotonin transporter gene (5-HTTLPR) variation: internalizing responses to everyday stress as a possible transdiagnostic phenotype

Table 2 Hierarchical linear models of 5-HTTLPR × daily life stress interactions: genotype coding

	Internalizing symptoms_t			Fear symptoms_t			Distress symptoms_t			Externalizing symptoms_t
Predictors	b	SE	P	b	SE	P	b	SE	P	b	SE	P
For overall intercept, π₀
Intercept, β₀₀	16.71	0.86	<0.001	6.63	0.32	<0.001	10.08	0.57	<0.001	10.05	0.39	<0.001
Gender, β₀₁	-1.96	1.11	0.081	-0.35	0.45	0.445	-1.61	0.69	0.021	-0.22	0.23	0.356
SS versus LL, β₀₃	1.46	1.17	0.216	0.75	0.47	0.110	0.71	0.76	0.356	-0.03	0.38	0.921
SL versus LL, β₀₄	1.49	1.11	0.184	0.52	0.43	0.232	0.96	0.73	0.190	0.00	0.39	0.994
For stress_t slope, π₁
Intercept, β₁₀	0.63	0.23	0.008	0.10	0.08	0.192	0.54	0.17	0.002	0.05	0.08	0.487
Gender, β₁₁	-0.85	0.30	0.006	-0.26	0.11	0.026	-0.58	0.22	0.010	0.09	0.13	0.464
SS versus LL, β₁₂	1.24	0.46	0.008	0.50	0.16	0.002	0.71	0.34	0.040	0.18	0.10	0.083
SL versus LL, β₁₃	1.18	0.36	0.002	0.36	0.13	0.007	0.77	0.28	0.007	0.16	0.10	0.139
For symptom_t-1 slope, π₂
Intercept, β₂₀	0.10	0.03	0.003	0.07	0.04	0.062	0.14	0.03	<0.001	0.01	0.05	0.753

Note. For gender, male = 1, female = 0. LL, 5-HTTLPR long allele homozygosity; SL, 5-HTTLPR heterozygosity; SE, standard error; SS, 5-HTTLPR short allele homozygosity.

ISSN: 2045-5380