Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder

Table 3 Change-point analysis of the BOLD responses to the social evaluative threat – average (intercept) across all participants

Region	x	y	Z	voxels	vol (mm³)	Peak t	Change-point onset	Change-point offset
Activation > Baseline
Instructions
Occipital cortex	2	−58	−4	3811	102897	18.22	64	106
Midbrain	2	−8	−10	197	5319	7.68	63	78
l. Superior Temporal G.	−52	−4	−2	138	3726	7.89	68	82
r. Superior Temporal G. & Insula	50	−16	4	284	7668	8.44	62	80
r. Inferior Frontal G.	44	28	16	121	3267	7.16	65	82
Early Speech Prep
Medial Frontal G.	4	38	20	73	1971	5.2	108	119
Late Speech Prep
No suprathreshold voxels
Recovery
r. Fusiform G.	32	−50	−14	98	2646	6.45	164	171
l. Parahippocampal G.	−26	−40	−14	83	2241	7.32	163	171
Precuneus	8	−62	22	200	5400	8.28	163	173
Posterior Cingulate G.	−16	−52	10	28	756	7.05	163	171
l. Superior Temporal G.	−50	−32	16	40	1080	5.04	165	177
l. Middle Frontal G.	−44	34	16	15	405	5.55	164	169
Activation < Baseline
Instructions
Middle Cingulate G./Bilateral Insula/Parietal Cortex	−8	−8	26	5617	151659	−11.87	63	88
r. Hippocampus	32	−22	−4	27	729	−6.09	66	71
r. Middle Temporal G.	34	52	8	24	648	−4.97	70	80
r. Caudate	22	−32	16	22	594	−5.72	65	71
r. Superior Temporal G.	40	−46	22	19	513	−5.39	63	66
Early Speech Prep
l. Posterior Cingulate G.	−26	−44	34	33	891	−6.19	106	117
Late Speech Prep
No suprathreshold voxels
Recovery
r. Thalamus	28	−26	−2	35	945	−5.82	165	169
l. Putamen	−32	−22	−2	50	1350	−5.84	165	170
r. Putamen	28	−8	8	78	2106	−6.55	164	171
l. Thalamus	−16	−22	10	25	675	−6.84	165	170
Anterior Cingulate G.	10	26	34	135	3645	−5.58	165	179

ISSN: 2045-5380