Study | Method | Participants | Results | Comments |
---|---|---|---|---|
Paul et al. [19] | ROI analysis 1.5 Tesla 12 non-colinear directions | 116 healthy subjects older than 18 years of age | Reduced FA within genu of corpus callosum in female subjects only who were exposed to significant ELS | ELS causes microstructural changes in brain that also occur in absence of clinically significant psychiatric symptoms |
Eluvathingal et al. [42] | ROI and tractography 1.5 Tesla 6 non-colinear directions | Seven right-handed children with history of early, severe socioemotional deprivation, seven matched controls | Significantly reduced FA values in left uncinate fasciculus in individuals exposed to ELS compared to controls | Structural changes in left uncinate fasciculus may contribute to cognitive and behavioural problems seen in ELS children |
Choi et al. [40] | TBSS 3 Tesla 12 encoding directions | 16 unmedicated individuals with history of high-level exposure to PVA but no other form of maltreatment, 16 matched controls | Reduced FA in arcuate fasciculus in left superior temporal gyrus, cingulum bundle by posterior tail of left hippocampus and left body of fornix | PVA exposure may cause alterations in integrity of neural pathways with consequences for language development and psychopathology |
Tomoda et al. [41] | Voxel-based whole-brain analysis 3 Tesla | 21 unmedicated, right-handed subjects ages 18 to 25 years with histories of PVA, 19 controls | An increase in grey matter volume by 14.1% in the left superior temporal gyrus | PVA exposure may affect development of auditory association cortex involved in language processing |
Jackowski et al. [43] | ROI analysis 1.5 Tesla 6 non-colinear directions | 17 maltreated children with PTSD, 15 controls | Reduced FA in medial and posterior corpus callosum of maltreated children | Alterations in areas of brain important in processing of emotional stimuli and memory function is associated with ELS |