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Fig. 3 | Biology of Mood & Anxiety Disorders

Fig. 3

From: Intolerance of uncertainty predicts fear extinction in amygdala-ventromedial prefrontal cortical circuitry

Fig. 3

Intolerance of uncertainty predicts right amygdala activation during fear extinction. a Right amygdala small volume correction from the (CS− > CS+)early > (CS− > CS+)late × IU contrast in extinction. b Significant correlations between percent signal change in the right amygdala for CS+ − CS− and IU scores during early and late extinction. High IU was associated with threat-like responses in the amygdala to CS− in early extinction and to CS+ in late extinction. These findings suggest high IU scorers generalize threat when faced with uncertainty, resulting in compromised safety learning. MNI coordinates: R right, L left

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