Influence of life stress, 5-HTTLPR genotype, and SLC6A4 methylation on gene expression and stress response in healthy Caucasian males

Table 4 Summary of the major study findings

	DNA methylation	Gene expression change in response to the TSST
		SLC6A4 expression: LL > S-group
Early life stress ↑	LINE-1 methylation: S-group ↔ LL ↑	SLC6A4 expression: S-group ↓ LL ↔
Early life stress ↑	F3 methylation: S-group ↑ LL ↔	SLC6A4 expression: S-group ↓ LL ↔
Chronic stress ↑	LINE-1 methylation: S-group ↔ LL ↑	F1 methylation correl w/ NR3C1 expression: S-group ↑ LL ↔
Chronic stress ↑	F1 methylation: S-group ↑ LL ↔	F1 methylation correl w/ NR3C1 expression: S-group ↑ LL ↔

Note. Arrows pointing up or down indicate significantly increased or decreased methylation/expression, respectively. Sideway arrows indicate no significant change.

ISSN: 2045-5380