Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder

Klumpp, Heide; Keutmann, Michael K; Fitzgerald, Daniel A; Shankman, Stewart A; Phan, K Luan

doi:10.1186/s13587-014-0014-5

Table 1 Whole-brain voxel-wise regression: relation between pre-treatment to post-treatment change in social anxiety severity, controlling for pre-treatment severity

From: Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder

		MNI coordinates			Volume
	Region	x	y	z	(mm ³)	Z
Right amygdala
Positive correlation	R rolandic operculum	30	−10	18	2,192	4.14
	L rolandic operculum	−36	−30	26	2,648	4.00
	L middle temporal gyrus	−58	−66	12	800	3.67
	L angular gyrus	−36	−70	48	552	3.38
	R frontal inferior triangularis	48	26	10	760	3.26
	L middle temporal gyrus	−66	−34	2	608	3.18
	L paracentral lobule	−8	−20	78	344	3.15
	R middle frontal gyrus	26	34	34	408	2.96
	L anterior cingulum	−4	48	0	392	2.90
Negative correlation	L parahippocampal gyrus	−14	2	−18	528	4.01
	L temporal pole superior gyrus	−26	14	−26	440	4.00
	R hippocampus	24	−10	−20	328	3.98
	R frontal superior orbital gyrus	16	16	−18	264	3.73
	R gyrus rectus	6	32	−18	760	3.69
	R frontal superior gyrus	16	66	26	360	3.64
	R frontal middle orbital gyrus	38	42	−10	512	3.64
	R frontal superior medial gyrus	10	40	56	352	3.48
	L cerebellum	−4	−40	−18	336	3.33
	L frontal middle orbital gyrus	−22	58	−10	296	3.04
	L fusiform gyrus	−32	−18	−18	360	2.18
Left amygdala
Positive correlation	L calcarine gyrus	−12	−60	16	1,136	4.44
	R temporal pole middle gyrus	32	18	−36	344	3.58
	R anterior cingulum	10	52	−2	928	3.30
	R frontal medial orbital gyrus				712	3.30
	L middle occipital gyrus	−38	−78	20	344	3.27
	R calcarine gyrus	8	−58	14	464	3.06
Negative correlation	L caudate	−18	−14	18	224	4.67
	R frontal middle orbital gyrus	36	64	−4	1,104	4.05
	L frontal middle gyrus	−44	20	48	1,104	3.97
	R inferior occipital gyrus	36	−64	−8	472	3.87
	L cerebellum	−42	−80	−22	784	3.77
	R frontal superior medial gyrus	6	42	52	1,744	3.74
	R frontal superior gyrus	14	68	24	576	3.68
	R cerebellum	4	−48	−44	432	3.60
	R frontal superior orbital gyrus	18	38	−16	376	3.53
	R frontal inferior orbital gyrus	36	38	−12	480	3.47
	L frontal middle orbital gyrus	−22	52	−10	360	3.36
	R superior parietal lobule	20	−62	60	440	3.21
	L cerebellum	−18	−90	−30	200	3.15
	R inferior temporal gyrus	56	−66	−8	296	3.00
	R frontal middle gyrus	42	16	54	168	2.84

All listed clusters are significant at p < 0.005 (uncorrected) with a threshold of greater than 160 volume (mm³).
Areas showing a priori hypothesized treatment-related predictors are bolded.
MNI Montreal Neurological Institute, Z Z-score.

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ISSN: 2045-5380

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