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Table 1 Whole-brain voxel-wise regression: relation between pre-treatment to post-treatment change in social anxiety severity, controlling for pre-treatment severity

From: Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder

   MNI coordinates Volume  
  Region x y z (mm 3) Z
Right amygdala       
Positive correlation R rolandic operculum 30 −10 18 2,192 4.14
  L rolandic operculum −36 −30 26 2,648 4.00
  L middle temporal gyrus −58 −66 12 800 3.67
  L angular gyrus −36 −70 48 552 3.38
  R frontal inferior triangularis 48 26 10 760 3.26
  L middle temporal gyrus −66 −34 2 608 3.18
  L paracentral lobule −8 −20 78 344 3.15
  R middle frontal gyrus 26 34 34 408 2.96
  L anterior cingulum −4 48 0 392 2.90
Negative correlation L parahippocampal gyrus −14 2 −18 528 4.01
  L temporal pole superior gyrus −26 14 −26 440 4.00
  R hippocampus 24 −10 −20 328 3.98
  R frontal superior orbital gyrus 16 16 −18 264 3.73
  R gyrus rectus 6 32 −18 760 3.69
  R frontal superior gyrus 16 66 26 360 3.64
  R frontal middle orbital gyrus 38 42 −10 512 3.64
  R frontal superior medial gyrus 10 40 56 352 3.48
  L cerebellum −4 −40 −18 336 3.33
  L frontal middle orbital gyrus −22 58 −10 296 3.04
  L fusiform gyrus −32 −18 −18 360 2.18
Left amygdala       
Positive correlation L calcarine gyrus −12 −60 16 1,136 4.44
  R temporal pole middle gyrus 32 18 −36 344 3.58
  R anterior cingulum 10 52 −2 928 3.30
  R frontal medial orbital gyrus     712 3.30
  L middle occipital gyrus −38 −78 20 344 3.27
  R calcarine gyrus 8 −58 14 464 3.06
Negative correlation L caudate −18 −14 18 224 4.67
  R frontal middle orbital gyrus 36 64 −4 1,104 4.05
  L frontal middle gyrus −44 20 48 1,104 3.97
  R inferior occipital gyrus 36 −64 −8 472 3.87
  L cerebellum −42 −80 −22 784 3.77
  R frontal superior medial gyrus 6 42 52 1,744 3.74
  R frontal superior gyrus 14 68 24 576 3.68
  R cerebellum 4 −48 −44 432 3.60
  R frontal superior orbital gyrus 18 38 −16 376 3.53
  R frontal inferior orbital gyrus 36 38 −12 480 3.47
  L frontal middle orbital gyrus −22 52 −10 360 3.36
  R superior parietal lobule 20 −62 60 440 3.21
  L cerebellum −18 −90 −30 200 3.15
  R inferior temporal gyrus 56 −66 −8 296 3.00
  R frontal middle gyrus 42 16 54 168 2.84
  1. All listed clusters are significant at p < 0.005 (uncorrected) with a threshold of greater than 160 volume (mm3).
  2. Areas showing a priori hypothesized treatment-related predictors are bolded.
  3. MNI Montreal Neurological Institute, Z Z-score.