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Figure 1 | Biology of Mood & Anxiety Disorders

Figure 1

From: Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder

Figure 1

Regressing LSAS change and scatterplot of regression analyses. (A) Regressing LSAS change (ΔPreTxPostTx) while initial severity (LSASPreTx) is controlled for as a regressor of no interest; brain map depicts whole-brain analysis of covariance showing enhanced left amygdala-anterior cingulate cortex/medial prefrontal cortex coupling during rest in gSAD displayed on statistical t-map at p < 0.005. (B) Scatterplot of regression analyses depicting extracted measures of left amygdala-anterior cingulate cortex/medial prefrontal cortex connectivity and relation to change in social anxiety severity. (C) Regressing LSAS change (ΔPreTx−PostTx) while baseline severity (LSASPreTx) is controlled for as a regressor of no interest; brain map depicts whole-brain analysis of covariance showing enhanced right amygdala-anterior cingulate cortex connectivity during rest in gSAD displayed on statistical t-map at p < 0.005. (D) Scatterplot of regression analyses depicting extracted measures of right amygdala-anterior cingulate cortex coupling and relation to change in social anxiety severity. (E) Regressing LSAS change (ΔPreTx−PostTx) while initial severity (LSASPreTx) is controlled for as a regressor of no interest; brain map depicts whole-brain analysis of covariance showing enhanced right amygdala-bilateral insula connectivity during rest in gSAD displayed on statistical t-map at p < 0.005. (F) Scatterplot of regression analyses illustrating extracted measures of right amygdala-bilateral insula coupling and relation to change in social anxiety severity. LSAS, Liebowitz Social Anxiety Scale; CBT, cognitive behavioral therapy; gSAD, generalized social anxiety disorder.

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