Figure 1

Regressing LSAS change and scatterplot of regression analyses. (A) Regressing LSAS change (Δ_{PreTx−PostTx}) while initial severity (LSAS_PreTx) is controlled for as a regressor of no interest; brain map depicts whole-brain analysis of covariance showing enhanced left amygdala-anterior cingulate cortex/medial prefrontal cortex coupling during rest in gSAD displayed on statistical t-map at p < 0.005. (B) Scatterplot of regression analyses depicting extracted measures of left amygdala-anterior cingulate cortex/medial prefrontal cortex connectivity and relation to change in social anxiety severity. (C) Regressing LSAS change (Δ_{PreTx−PostTx}) while baseline severity (LSAS_PreTx) is controlled for as a regressor of no interest; brain map depicts whole-brain analysis of covariance showing enhanced right amygdala-anterior cingulate cortex connectivity during rest in gSAD displayed on statistical t-map at p < 0.005. (D) Scatterplot of regression analyses depicting extracted measures of right amygdala-anterior cingulate cortex coupling and relation to change in social anxiety severity. (E) Regressing LSAS change (Δ_{PreTx−PostTx}) while initial severity (LSAS_PreTx) is controlled for as a regressor of no interest; brain map depicts whole-brain analysis of covariance showing enhanced right amygdala-bilateral insula connectivity during rest in gSAD displayed on statistical t-map at p < 0.005. (F) Scatterplot of regression analyses illustrating extracted measures of right amygdala-bilateral insula coupling and relation to change in social anxiety severity. LSAS, Liebowitz Social Anxiety Scale; CBT, cognitive behavioral therapy; gSAD, generalized social anxiety disorder.