Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder

Table 2 White matter clusters with reduced fractional anisotropy (FA) in pediatric OCD patients versus healthy controls

Cluster label and anatomical localization	Voxels	MNI coordinates			FA
		x	y	z	OCD	HC	p
1. Bilateral frontal (ATR, UF, IFOF, forceps minor, anterior corona radiata) and corpus callosum (genu, body, splenium)	9,022	20	37	6	0.533 ± 0.191	0.573 ± 0.188	0.026
2. Right cingulate and basal ganglia: anterior cingulate cortex (UF), anterior limb of IC (ATR), putamen (UF), amygdala (ILF), cerebral peduncle (CST), thalamus, and posterior limb of IC (ATR)	1,454	23	0	−9	0.419 ± 0.157	0.460 ± 0.158	0.035
3. Right posterior cerebral cortex: lateral occipital and angular gyri (SLF)	132	36	−56	33	0.423 ± 0.100	0.500 ± 0.098	0.048
4. Right inferior frontal lobe (subcallosal cortex)	50	8	21	−19	0.296 ± 0.067	0.370 ± 0.107	0.049
5. Right inferior frontal: orbitofrontal cortex	36	8	37	−22	0.267 ± 0.067	0.323 ± 0.073	0.050
6. Right thalamus	14	18	−5	11	0.639 ± 0.041	0.668 ± 0.038	0.050
7. Right caudate, anterior IC (ATR)	6	22	−4	24	0.430 ± 0.056	0.493 ± 0.081	0.050

ATR anterior thalamic radiation, CST corticospinal tract, IC internal capsule, IFOF inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus, UF uncinate fasciculus.

ISSN: 2045-5380