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Table 2 Whole-brain results for the valence-by-group analysis of variance during the unpredictable and predictable conditions

From: Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression

Model Region MNI coordinates Voxels Z-score
  X Y Z   
Group by valence interaction      
 U conditions R medial frontal gyrus 14 -16 58 157 3.80
  L insula -36 -2 18 1,162 3.78
  R insula 34 -20 20 315 3.48
 P conditions L medial frontal gyrus -16 -4 54 136 3.72
  R inferior frontal lobe 2 0 -18 456 3.57
  L parietal lobe -28 -42 42 292 3.53
  L inferior temporal lobe -46 -54 -10 413 3.44
  L posterior cingulate cortex -8 -40 34 198 3.05
Main effect of group      
 U conditions L cerebellum -20 -84 -32 118 3.15
 P conditions L lingual gyrus -18 -80 -4 223 4.05
Main effect of valence      
 U conditions R middle frontal gyrus 54 18 40 6,501 5.48
  R inferior frontal gyrus 36 22 -18 23,489 5.13
  L middle frontal gyrus -42 6 58 5,435 4.48
  R medial frontal gyrus 6 44 42 669 4.31
  R cuneus 4 -98 6 221 3.27
 P conditions R frontal lobe 22 -4 28 138 3.32
  R cerebellum 24 -50 -38 67 3.16
  1. Note. Reporting of all clusters exhibiting significance at p < 0.05 (corrected). L left, R right, MNI Montreal Neurologic Institute, U conditions anticipation of unpredictable negative and neutral images, P conditions anticipation of predictable negative and neutral images.