Figure 1

Voxelwise statistical F -map on a canonical brain displaying significant valence × group interactions in neural responses to unpredictable conditions. Color scale reflects F-value. Bar graph illustrating extracted parameter estimates from the left and right insula cortices during anticipation of unpredictable negative images and unpredictable neutral images. Controls no history of psychopathology, MDD-only current diagnosis of major depressive disorder and no lifetime history of an anxiety disorder, PD-MDD current diagnoses of major depressive disorder and panic disorder.