Connectivity. Connectivity analyses revealed a pattern of positive connectivity between BOLD reactivity in emotion processing and controlling areas in PMDD between the (A) amygdala and ACC (two clusters marked in red and yellow respectively: 3, 27, 15; k = 90; z = 3.53; p <0.001; and 12, 44, 3; k = 29; z = 2.68; p <0.016) and the (B) insula and ACC (two clusters marked in red and yellow respectively: 15, 33, 23; k = 7; z = 2.45; p = 0.008; and 6, 29, −4; k = 11; z = 2.46; p = 0.007). (C) For healthy controls there was a trend towards a negative relation between the ACC and insula (6, 33, 18; k = 9; z = 1.89; p = 0.029). All anatomic localizations are given in Talairach coordinates. Brighter colors represent higher t scores. Below the brain images, schematic representations of the connectivity are given for each cluster. Three outliers with BOLD reactivity >2 SD from mean of group were excluded from analyses. ACC, anterior cingulate cortex; PMDD, premenstrual dysphoric disorder.