Hormone levels. (A) Progesterone and (B) estradiol levels in women with PMDD and healthy controls during the follicular and luteal phase of the menstrual cycle. In both groups, progesterone increased significantly in the luteal phase whereas estradiol was similar across phases. No significant group differences emerged in either phase. **p <0.001. HC, healthy controls; PMDD, premenstrual dysphoric disorder.