TY - JOUR AU - Kim, M. Justin AU - Neta, Maital AU - Davis, F. Caroline AU - Ruberry, Erika J. AU - Dinescu, Diana AU - Heatherton, Todd F. AU - Stotland, Mitchell A. AU - Whalen, Paul J. PY - 2014 DA - 2014/10/31 TI - Botulinum toxin-induced facial muscle paralysis affects amygdala responses to the perception of emotional expressions: preliminary findings from an A-B-A design JO - Biology of Mood & Anxiety Disorders SP - 11 VL - 4 IS - 1 AB - It has long been suggested that feedback signals from facial muscles influence emotional experience. The recent surge in use of botulinum toxin (BTX) to induce temporary muscle paralysis offers a unique opportunity to directly test this “facial feedback hypothesis.” Previous research shows that the lack of facial muscle feedback due to BTX-induced paralysis influences subjective reports of emotional experience, as well as brain activity associated with the imitation of emotional facial expressions. However, it remains to be seen whether facial muscle paralysis affects brain activity, especially the amygdala, which is known to be responsive to the perception of emotion in others. Further, it is unknown whether these neural changes are permanent or whether they revert to their original state after the effects of BTX have subsided. The present study sought to address these questions by using functional magnetic resonance imaging to measure neural responses to angry and happy facial expressions in the presence or absence of facial paralysis. SN - 2045-5380 UR - https://doi.org/10.1186/2045-5380-4-11 DO - 10.1186/2045-5380-4-11 ID - Kim2014 ER -