| Reference | Patients | Controls | Patients + controls | Difference | Effect size | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
 |  | Number | Volume ± SD | Number | Volume ± SD | N | Variance | Estimate | Variance | Estimate | Variance |
Study 1 | [46] | 18 | 773 ± 56 | 18 | 822 ± 56 | 36 | 3,114 | -49 | 346 | -0.854 | 0.122 |
Study 2 | [47] | 55 | 685 ± 74 | 50 | 708 ± 72 | 105 | 5,323 | -23 | 203 | -0.313 | 0.039 |
Study 3 | [48] | 25 | 850 ± 83 | 25 | 834 ± 71 | 50 | 5,997 | +16 | 480 | 0.196 | 0.080 |
Study 4 | [49] | 72 | 739 ± 82 | 72 | 763 ± 78 | 144 | 6,404 | -24 | 178 | -0.298 | 0.028 |
Study 5 | [50] | 37 | 776 ± 69 | 26 | 747 ± 68 | 63 | 4,680 | +29 | 307 | 0.418 | 0.067 |
Study 6 | [51] | 19 | 827 ± 44 | 15 | 836 ± 63 | 34 | 3,041 | -9 | 363 | -0.179 | 0.120 |
Study 7 | [52] | 71 | 740 ± 66 | 71 | 738 ± 63 | 142 | 4,119 | +2 | 116 | 0.035 | 0.028 |