Table 2 Biological pathways identified by GeneGO metacore pathway analysis as differing over time between BD subjects who responded or failed to respond to treatment with lithium

1

Apoptosis_Anti-Apoptosis mediated by external signals

0.013

2

Apoptosis_Apoptotic mitochondria

0.055

3

Cytoskeleton_Actin filaments

0.055

4

Apoptosis_Endoplasmic reticulum stress pathway

0.068

5

Cell cycle_Core

0.110

6

Protein folding_Folding in normal condition

0.117

7

Cell cycle_G1-S Interleukin regulation

0.123

8

Development_Hemopoiesis, Erythropoietin pathway

0.143

9

Immune response_BCR pathway

0.147

10

Apoptosis_Apoptosis stimulation by external signals

0.159

Week 4: down-regulated genes in Lithium responders vs. non-responders

1

Apoptosis_Apoptotic mitochondria

0.053

2

Apoptosis_Endoplasmic reticulum stress pathway

0.060

3

Signal transduction_Nitric oxide signaling

0.061

4

Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen

0.068

5

Protein folding_Folding in normal condition

0.081

6

Proteolysis_Proteolysis in cell cycle and apoptosis

0.085

7

Development_Hemopoiesis, Erythropoietin pathway

0.092

8

Apoptosis_Apoptosis stimulation by external signals

0.098

9

Proliferation_Negative regulation of cell proliferation

0.123

10

Cell adhesion_Amyloid proteins

0.127

Week 4: up-regulated genes in Lithium responders vs. non-responders

1

Cell adhesion_Glycoconjugates

0.010

2

Apoptosis_Anti-Apoptosis mediated by external signals via PI3K/AKT

0.017

3

Autophagy_Autophagy

0.053

4

Signal transduction_Androgen receptor signaling cross-talk

0.069

5

Signal transduction_ERBB-family signaling

0.072

6

Cytoskeleton_Macropinocytosis and its regulation

0.081

7

Inflammation_IL-13 signaling pathway

0.087

8

Signal transduction_Leptin signaling

0.098

9

Signal Transduction_Cholecystokinin signaling

0.100

10

Inflammation_IL-4 signaling

0.108

Week 6: down-regulated genes in Lithium responders vs. non-responders

1

Cell cycle_Core

0.027

2

Development_Hemopoiesis, Erythropoietin pathway

0.036

3

Response to hypoxia and oxidative stress

0.053

4

Transport_Synaptic vesicle exocytosis

0.059

5

Cell cycle_G0-G1

0.149

6

Neurophysiological process_Long-term potentiation

0.170

7

Blood coagulation

0.193

8

Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen

0.202

9

Inflammation_IL-6 signaling

0.238

10

Cell cycle_G1-S Interleukin regulation

0.245

Week 6: up-regulated genes in Lithium responders vs. non-responders

1

Development_Skeletal muscle development

0.024

2

Cell adhesion_Attractive and repulsive receptors

0.034

3

Cytoskeleton_Actin filaments

0.034

4

Development_Neurogenesis:Axonal guidance

0.056

5

Protein folding_ER and cytoplasm

0.074

6

Protein folding_Response to unfolded proteins

0.111

7

Apoptosis_Apoptotic mitochondria

0.123

8

Apoptosis_Endoplasmic reticulum stress pathway

0.138

9

Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen

0.156

10

Protein folding_Folding in normal condition

0.184