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Table 2 Biological pathways identified by GeneGO metacore pathway analysis as differing over time between BD subjects who responded or failed to respond to treatment with lithium

From: Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation

GeneGO Process Networks for genes showing significant group x time interaction
Overall   p-Value
1 Apoptosis_Anti-Apoptosis mediated by external signals 0.013
2 Apoptosis_Apoptotic mitochondria 0.055
3 Cytoskeleton_Actin filaments 0.055
4 Apoptosis_Endoplasmic reticulum stress pathway 0.068
5 Cell cycle_Core 0.110
6 Protein folding_Folding in normal condition 0.117
7 Cell cycle_G1-S Interleukin regulation 0.123
8 Development_Hemopoiesis, Erythropoietin pathway 0.143
9 Immune response_BCR pathway 0.147
10 Apoptosis_Apoptosis stimulation by external signals 0.159
Week 4: down-regulated genes in Lithium responders vs. non-responders
1 Apoptosis_Apoptotic mitochondria 0.053
2 Apoptosis_Endoplasmic reticulum stress pathway 0.060
3 Signal transduction_Nitric oxide signaling 0.061
4 Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen 0.068
5 Protein folding_Folding in normal condition 0.081
6 Proteolysis_Proteolysis in cell cycle and apoptosis 0.085
7 Development_Hemopoiesis, Erythropoietin pathway 0.092
8 Apoptosis_Apoptosis stimulation by external signals 0.098
9 Proliferation_Negative regulation of cell proliferation 0.123
10 Cell adhesion_Amyloid proteins 0.127
Week 4: up-regulated genes in Lithium responders vs. non-responders
1 Cell adhesion_Glycoconjugates 0.010
2 Apoptosis_Anti-Apoptosis mediated by external signals via PI3K/AKT 0.017
3 Autophagy_Autophagy 0.053
4 Signal transduction_Androgen receptor signaling cross-talk 0.069
5 Signal transduction_ERBB-family signaling 0.072
6 Cytoskeleton_Macropinocytosis and its regulation 0.081
7 Inflammation_IL-13 signaling pathway 0.087
8 Signal transduction_Leptin signaling 0.098
9 Signal Transduction_Cholecystokinin signaling 0.100
10 Inflammation_IL-4 signaling 0.108
Week 6: down-regulated genes in Lithium responders vs. non-responders
1 Cell cycle_Core 0.027
2 Development_Hemopoiesis, Erythropoietin pathway 0.036
3 Response to hypoxia and oxidative stress 0.053
4 Transport_Synaptic vesicle exocytosis 0.059
5 Cell cycle_G0-G1 0.149
6 Neurophysiological process_Long-term potentiation 0.170
7 Blood coagulation 0.193
8 Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen 0.202
9 Inflammation_IL-6 signaling 0.238
10 Cell cycle_G1-S Interleukin regulation 0.245
Week 6: up-regulated genes in Lithium responders vs. non-responders
1 Development_Skeletal muscle development 0.024
2 Cell adhesion_Attractive and repulsive receptors 0.034
3 Cytoskeleton_Actin filaments 0.034
4 Development_Neurogenesis:Axonal guidance 0.056
5 Protein folding_ER and cytoplasm 0.074
6 Protein folding_Response to unfolded proteins 0.111
7 Apoptosis_Apoptotic mitochondria 0.123
8 Apoptosis_Endoplasmic reticulum stress pathway 0.138
9 Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen 0.156
10 Protein folding_Folding in normal condition 0.184
  1. Pathway analysis was conducted for the entire group of 127 genes showing a significant group x time interaction, as well as for up-regulated and down-regulated genes separately at each of the time-points where significant differences were seen (4 weeks and 6 weeks after treatment initiation).