Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder

Table 5 Change-point analysis of the BOLD responses to the social evaluative threat task of participants with and without social anxiety disorder

Region	x	y	z	voxels	vol (mm³)	Peak t	change-point onset	change-point offset	comorbid (~,>,<) social anxiety
Social Anxiety > No Social Anxiety
Instructions
Cerebellum: Declive*	8	−58	−14	325	8775	12.52	66	102	<
r. Lingual G.*	26	−74	−2	15	405	5.34	69	79	<
r. Superior Temporal G.	56	−38	4	31	837	7.68	66	83	~
Early Speech Prep
No suprathreshold voxels
Late Speech Prep
No suprathreshold voxels
Recovery
r. Cerebellum: Declive*	26	−56	−20	142	3834	9.03	164	174	<
l. Cerebellum: Declive	−20	−62	−20	83	2241	7.45	163	171	~
No Social Anxiety > Social Anxiety
Instructions
l. Insula	−32	8	−4	54	1458	−7.21	68	80
r. Precentral G.	50	−8	22	151	4077	−6.6	67	81	~
l. Inferior Frontal G.*	−52	8	10	66	1782	−6.62	68	86	>
r. Middle Frontal G.	34	52	8	19	513	−7.21	68	82	~
Cingulate G.	4	−8	34	237	6399	−7.91	66	91
l. Cingulate/Supramarginal G.	−26	−26	38	159	4293	−6.94	66	81	~
Early Speech Prep
No suprathreshold voxels
Late Speech Prep
No suprathreshold voxels
Recovery
r. Insula	44	−2	−2	103	2781	−6.67	164	184	~
l. Insula	−40	4	2	124	3348	−7.4	164	184	~
l. Postcentral G.	−38	−20	38	29	783	−6.89	166	177	~

Note. These clusters were masked with the clusters that exhibited group average activation differences during the social evaluative threat task. vol = volume; G. = Gyrus. ¹ Post-hoc group contrasts that test whether comorbid participants exhibited similar (~; not significantly different from each other, but both groups are different than control participants), greater (>), or less (<) activation than participants with pure social anxiety (p < .05). The lack of a symbol means that comorbid participants did not exhibit significantly different activation than control participants and participants with pure social anxiety.
* Those regions for which comorbid participants’ activation significantly differed from both pure depression and pure social anxiety groups.

ISSN: 2045-5380