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Table 3 Paired comparisons between healthy controls (HC, n = 24), family history negative healthy participants (FHN, n = 14), family history positive healthy participants (FHP, n = 10) and patients with major depressive disorder (MDD, n = 14)

From: Functional anomalies in healthy individuals with a first degree family history of major depressive disorder

Contrast Comparison Region Region of interest P (FWE correction) Ke T P uncorrected x y z
F > N MDD < HC Left middle cingulum 0.041 (cluster corr.) 71 3.82 < 0.001 -15 -28 37
   Left insula 0.072 8 4.19 < 0.001 -27 29 7
  MDD < FHN Left insula < 0.033 11 4.43 < 0.001 -27 29 7
   Left post-central gyrus ns 29 3.59 < 0.001 -27 -28 37
  MDD > FHN - ns - - ns - - -
  MDD < FHP - ns - - ns - - -
  MDD > FHP - ns - - ns - - -
  FHP > FHN Right Heschl's gyrus 0.018 17 4.60 < 0.001 51 -28 13
  FHP < FHN - ns - - ns - - -
F < N FHP < FHN Right Heschl's gyrus 0.002 26 5.22 < 0.001 51 -28 13
  MDD < FHP - ns - - ns - - -
  MDD > FHP - ns - - ns - - -
  1. F > N: "fear" > "neutral" contrast; F < N: "fear" < "neutral" contrast; FWE: family wise error correction; Ke: number of significant voxels; ns: not significant; T: t-value; x, y, z: coordinates in the Montreal Neurological Institute system.