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Table 3 The criteria of validity for animal models.

From: Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression

Kind of validity Aspect of validity Object of validity (animal/human similarity of...)
homological validity species validity Species
  strain validity strain
pathogenic validity ontopathogenic validity interaction transforming an initial organism into a vulnerable organism.
  triggering validity interaction transforming an initial or a vulnerable organism into a pathological organism.
mechanistic validity theoretical cognitive or neurobiological mechanisms producing the observable effects of the disease.
face validity ethological validity behavioral symptoms of the disease
  biomarker validity biomarkers associated with the disease
predictive validity induction validity relation between the triggering factor and the observable effects of the disease.
  remission validity relation between the therapeutic agent and the observable effects of the disease.