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Table 3 The criteria of validity for animal models.

From: Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression

Kind of validity

Aspect of validity

Object of validity (animal/human similarity of...)

homological validity

species validity

Species

Ā 

strain validity

strain

pathogenic validity

ontopathogenic validity

interaction transforming an initial organism into a vulnerable organism.

Ā 

triggering validity

interaction transforming an initial or a vulnerable organism into a pathological organism.

mechanistic validity

theoretical cognitive or neurobiological mechanisms producing the observable effects of the disease.

face validity

ethological validity

behavioral symptoms of the disease

Ā 

biomarker validity

biomarkers associated with the disease

predictive validity

induction validity

relation between the triggering factor and the observable effects of the disease.

Ā 

remission validity

relation between the therapeutic agent and the observable effects of the disease.