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Table 4 Psychophysiological interaction analysis

From: An fMRI study of unconditioned responses in post-traumatic stress disorder

Seed

MNIa, peak x, y, z

Z-score

Size, voxels

Cluster Pvalue, FWEb

Regionc

Left putamen

     

   TENCd > PTSDe

-44, -12, -16

4.65

295

0.01

Left temporal lobe

 

(-32, 0, -30)

4.01

  

Left parahippocampal lobe/amygdala

 

(-30, -10, -22)

3.72

  

Left parahippocampal gyrus

   PTSD > TENC

No significant differences

   

Right putamen

     

   TENC > PTSD

-30, 0, -32

4.54

248

0.019

Left temporal lobe wm/amygdala

 

(-48, 8, -30)

3.97

  

Left middle temporal gyrus

 

(-56, 4, -26)

3.44

  

Left middle temporal gyrus

   PTSD > TENC

No significant differences

   

Left middle frontal gyrus

     

   TENC > PTSD

No significant differences

   

   PTSD > TENC

No significant differences

   

Left parahippocampal gyrus

     

   TENC > PTSD

44, -34, 42

4.45

449

0.001

Right inferior parietal lobule

 

48, -38, 50

-4.27

  

Right inferior parietal lobule

 

52, -26, 50

-3.77

  

Right postcentral gyrus

 

-10, 66, 10

4.42

263

0.017

Left medial frontal gyrus

 

(-14, 62, 0)

-4.06

  

Left medial frontal gyrus

 

(-8, 62, 18)

-3.45

  

Left medial frontal gyrus

 

34, -20, 68

4.37

487

0.001

Right precentral gyrus

 

(34, -16, 46)

-4.14

  

Right precentral gyrus

 

(22, -16, 74)

-4.12

  

Right precentral gyrus

   PTSD > TENC

No significant differences

   
  1. aMontreal Neurological Institute.
  2. bFamily-wise error.
  3. cRegions were identified based on nearest gray matter.
  4. dPost-traumatic stress disorder.
  5. eTrauma-exposed normal control.