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Table 3 Summary of the studies which included P200 component

From: Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis

Study Study Groups Paradigm Findings
[31] 12 combat PTSD veterans
6 normal controls
Four tones intensity paradigm Reduced P2 amplitude intensity slope in PTSD subjects
[25] 13 female with sexual assault PTSD
16 healthy controls
Auditory oddball Reduced amplitude and latency in response to deviant stimuli
[28] 17 civil PTSD
17 healthy controls
Auditory oddball Smaller P200 to target and common tones. Earlier response to common but not target tones.
[30] 36 civil PTSD
20 healthy
10 depressed
8 alcoholics.
2000-Hz tone presented in intensity blocks of 65, 72.5, 80, 87.5, and 95 dB (SPL) In normal subjects, depressed, and alcoholics, there was linear relationship between the tone intensity and P200 amplitude, which was not the case in combat related PTSD subjects.
[32] 29 PTSD nurse veterans
38 non-PTSD
Four-tone stimulus-intensity modulation paradigm Increased P2 amplitude/intensity slope
[35] 10 civil PTSD
10 controls
Auditory oddball No difference in P2 amplitude or latency
[29] 7 PTSD motor vehicle accident (MVA)
7 non-PTSD with MVA
Visual presentation of trauma related/unrelated/neutral pictures Smaller P200 amplitude
Larger response to trauma-related images in non-PTSD and healthy controls
[36] 14 PTSD [mixed etiologies]
12 controls
Auditory oddball No difference in P200 amplitude
[33] 12 combat exposed veterans with PTSD and 33 without PTSD and their twins Four-tone stimulus-intensity modulation paradigm Increased P2 amplitude intensity slope in PTSD veterans.
P2 amplitude intensity slopes were related to higher combat exposure, CAPS Total, and re-experience symptoms severity scores in the
combat-exposed veterans but not to the remaining PTSD symptom cluster scores or the SCL-90-R (Symptom Checklist 90 Revised) general psychopathology, anxiety, or depression subscale scores.
Higher combat-exposure scores, but not CAPS Total or subscale scores, were also related to increased P2 amplitude.
[34] 12 PTSD and 12 control survivors of earthquake Subliminal visual presentation of earthquake-related/unrelated words Increased P2 amplitude in the PTSD group in response to the trauma-related stimuli