Table 3 Summary of the studies which included P200 component
From: Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis
Study | Study Groups | Paradigm | Findings |
|---|---|---|---|
[31] | 12 combat PTSD veterans 6 normal controls | Four tones intensity paradigm | Reduced P2 amplitude intensity slope in PTSD subjects |
[25] | 13 female with sexual assault PTSD 16 healthy controls | Auditory oddball | Reduced amplitude and latency in response to deviant stimuli |
[28] | 17 civil PTSD 17 healthy controls | Auditory oddball | Smaller P200 to target and common tones. Earlier response to common but not target tones. |
[30] | 36 civil PTSD 20 healthy 10 depressed 8 alcoholics. | 2000-Hz tone presented in intensity blocks of 65, 72.5, 80, 87.5, and 95 dB (SPL) | In normal subjects, depressed, and alcoholics, there was linear relationship between the tone intensity and P200 amplitude, which was not the case in combat related PTSD subjects. |
[32] | 29 PTSD nurse veterans 38 non-PTSD | Four-tone stimulus-intensity modulation paradigm | Increased P2 amplitude/intensity slope |
[35] | 10 civil PTSD 10 controls | Auditory oddball | No difference in P2 amplitude or latency |
[29] | 7 PTSD motor vehicle accident (MVA) 7 non-PTSD with MVA | Visual presentation of trauma related/unrelated/neutral pictures | Smaller P200 amplitude Larger response to trauma-related images in non-PTSD and healthy controls |
[36] | 14 PTSD [mixed etiologies] 12 controls | Auditory oddball | No difference in P200 amplitude |
[33] | 12 combat exposed veterans with PTSD and 33 without PTSD and their twins | Four-tone stimulus-intensity modulation paradigm | Increased P2 amplitude intensity slope in PTSD veterans. P2 amplitude intensity slopes were related to higher combat exposure, CAPS Total, and re-experience symptoms severity scores in the combat-exposed veterans but not to the remaining PTSD symptom cluster scores or the SCL-90-R (Symptom Checklist 90 Revised) general psychopathology, anxiety, or depression subscale scores. Higher combat-exposure scores, but not CAPS Total or subscale scores, were also related to increased P2 amplitude. |
[34] | 12 PTSD and 12 control survivors of earthquake | Subliminal visual presentation of earthquake-related/unrelated words | Increased P2 amplitude in the PTSD group in response to the trauma-related stimuli |