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Table 3 Summary of diffusion tensor imaging studies included in our meta-analysis conducted in patients with major depressive disorder using corrected whole-brain voxel-based analysisa

From: Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression

Study Method Participants Results Comments
Kieseppä et al. [18] Voxel-based analysis
1.5 Tesla
12 non-colinear directions
16 middle-aged MDD patients and 20 controls Reduced FA in the left sagittal stratum, cingulate cortex and posterior corpus callosum Reduced FA in left SLF (temporoparietal) and in the right cingulum in patients with MDD
Zhu et al. [58] TBSS
1.5 Tesla
13 non-colinear directions
25 young first-episode MDD patients and 25 matched controls Reduced FA in the left anterior limb of the internal capsule, right parahippocampal gyrus and left posterior cingulate cortex FA values in the left anterior limb of the internal capsule and right cingulum (hippocampus) and left cingulum (dorsal part) were negatively correlated with symptom severity
Abe et al. [59] Voxel-based analysis
1.5 Tesla
6 non-colinear directions
21 young MDD patients and 42 controls No significant difference between groups for FA and WM volume Negative correlation between FA and total days depressed in both the right anterior cingulate and the left frontal WM
Blood et al. [24] Voxel-based analysis
3.0 Tesla
6 non-colinear directions
22 MDD patients and 22 controls Increased FA in the right ventral tegmental area and reduced FA in DLPFC WM in MDD subjects Increased FA in right corticospinal tract, decreased FA in left corticospinal tract, right inferior FOF (frontal lobe), bilateral DLPFC, left SLF (temporal)
Wu et al. [25] Voxel-based analysis
3.0 Tesla
13 non-colinear directions
23 single-episode, medication-naive MDD subjects and 21 controls FA reduction in right SLF, right middle frontal and left
parietal WM with MDD
Reduced FA in left SLF (parietal lobe) and right frontal WM with MDD
Jia et al. [26] Voxel-based analysis
3.0 Tesla
15 non-colinear directions
52 MDD patients, 16 with and 36 without a history of suicide attempts, and 52 matched controls Reduced FA in the left anterior limb of the internal capsule in suicide attempters relative to both nonattempters and controls Reduced FA in bilateral SLF (parietal lobe) and cerebellum
Korgaonkar et al. [60] Voxel-based analysis
3.0 Tesla
42 different diffusion orientations
29 MDD subjects and 39 controls 7.8% reduction in FA in the limbic system, DLPFC, thalamic projection fibres, and corpus callosum Limbic-DLPFC-thalamic axis Dysfunction may be involved in MDD
  1. aMDD, major depressive disorder; FA, fractional anisotropy; SLF, superior longitudinal fasciculus; TBSS, tract-based spatial statistics; FOF, fronto-occipital fasciculus; DLPFC, dorsolateral prefrontal cortex; WM, white matter.