Amygdala activation to threat under attentional load in individuals with anxiety disorder

Table 3 Significant brain activation

Area	Side	x	y	z	Size (mm³)	F value	Signal change (%)
Main effect load (ROI):
Amygdala	R	27	-10	-11	2571	55.54	0.35
	L	-25	-8	-12	2771	45.09	0.35
Insula	R	33	15	11	1674	54.72	0.43
	L	-35	15	12	1431	59.68	0.43
FG	L	-45	-55	-14	662	45.06	0.49
Dorsal ACC	R/L	-7	43	11	10652	65.54	0.70
DMPFC	R/L	-10	43	15	8391	54.61	0.45
DLPFC	R	23	23	52	1489	42.11	0.38
	L	-19	28	52	3604	57.51	0.53
Main effect load (whole brain):
Parietal cortex	R	2	-53	21	11751	62.70	0.76
	L	-25	-66	34	17118	103.44	0.83
VMPFC	R/L	-7	43	9	4503	71.67	0.70
Visual cortex	R	3	-77	-7	373	23.06	0.37
	L	-3	-81	-8	328	27.06	0.36
Main effect picture (whole brain):
STG	R	53	-14	-3	377	13.12	0.14
Visual cortex	R	16	-93	-5	783	20.79	0.19
	L	-18	-94	-10	513	22.57	0.21
Interaction picture by group (ROI):
Amygdala	R	23	-1	-11	116	11.54	0.40
	L	-27	-1	-17	108	10.15	0.35
FG	L	-42	-55	-11	179	12.11	0.32

x, y, z are the Talairach coordinates of peak voxel activation threshold: P < 0.05, corrected. Cluster threshold whole brain: 11 voxels; other thresholds: 3 to 5 voxels; voxel threshold: P < 0.005.
ACC = anterior cingulate cortex; DLPFC = dorsolateral prefrontal cortex; DMPFC = dorsomedial prefrontal cortex; FG = fusiform gyrus; ROI = region of interest; STG = superior temporal gyrus; VMPFC = ventromedial prefrontal cortex.

ISSN: 2045-5380